Skin-resident antigen-presenting cells: instruction manual for vaccine development

被引：47

作者：

Fehres, Cynthia M. ^{[1
]}

Garcia-Vallejo, Juan J. ^{[1
]}

Unger, Wendy W. J. ^{[1
]}

van Kooyk, Yvette ^{[1
]}

机构：

[1] Vrije Univ Amsterdam, Med Ctr, Dept Mol Cell Biol & Immunol, NL-1007 MB Amsterdam, Netherlands

来源：

FRONTIERS IN IMMUNOLOGY | 2013年 / 4卷

关键词：

skin; antigen-presenting cells; vaccination; microneedles; C-type lectin receptors; glycans; PLASMACYTOID DENDRITIC CELLS; CD8(+) T-CELLS; LANGERHANS CELLS; ADOPTIVE IMMUNOTHERAPY; HUMAN KERATINOCYTES; DC-SIGN; ANTITUMOR; SUBSETS; RESPONSES; PROSTATE;

D O I：

10.3389/fimmu.2013.00157

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The induction of antigen-specific effector T cells is driven by proper antigen presentation and co-stimulation by dendritic cells (DCs). For this reason strategies have been developed to instruct DCs for the induction of CD4(+) and CD8(+) T cell responses. Since DCs are localized, amongst other locations, in peripheral tissues such as the skin, new vaccines are aiming at targeting antigens to DCs in situ. Optimal skin-DC targeting in combination with adequate adjuvant delivery facilitates DC maturation and migration to draining lymph nodes and enhances antigen cross-presentation and T cell priming. In this review we describe what DC subsets populate the human skin, as well as current vaccination strategies based on targeting strategies and alternative administration for the induction of robust long-lived anti-cancer effector T cells.

引用

页数：8

共 55 条

[1] Adjuvants for human vaccines [J].

Alving, Carl R. ;

Peachman, Kristina K. ;

Rao, Mangala ;

Reed, Steven G. .

CURRENT OPINION IN IMMUNOLOGY, 2012, 24 (03) :310-315

[2] CD14+ antigen-presenting cells in human dermis are less mature than their CD1a+ counterparts [J].

Angel, Catherine E. ;

Lala, Aisha ;

Chen, Chun-Jen J. ;

Edgar, Stephen G. ;

Ostrovsky, Lena L. ;

Dunbar, P. Rod .

INTERNATIONAL IMMUNOLOGY, 2007, 19 (11) :1271-1279

[3] Langerin negative dendritic cells promote potent CD8+ T-cell priming by skin delivery of live adenovirus vaccine microneedle arrays [J].

Bachy, Veronique ;

Hervouet, Catherine ;

Becker, Pablo D. ;

Chorro, Laurent ;

Carlin, Leo M. ;

Herath, Shanthi ;

Papagatsias, Timos ;

Barbaroux, Jean-Baptiste ;

Oh, Sea-Jin ;

Benlahrech, Adel ;

Athanasopoulos, Takis ;

Dickson, George ;

Patterson, Steven ;

Kwon, Sung-Yun ;

Geissmann, Frederic ;

Klavinskis, Linda S. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2013, 110 (08) :3041-3046

[4] The differential production of cytokines by human Langerhans cells and dermal CD14+ DCs controls CTL priming [J].

Banchereau, Jacques ;

Thompson-Snipes, Luann ;

Zurawski, Sandra ;

Blanck, Jean-Philippe ;

Cao, Yanying ;

Clayton, Sandra ;

Gorvel, Jean-Pierre ;

Zurawski, Gerard ;

Klechevsky, Eynav .

BLOOD, 2012, 119 (24) :5742-5749

[5]

Begon E, 2007, EUR J DERMATOL, V17, P497

[6] Autocrine/paracrine TGF-β1 inhibits Langerhans cell migration [J].

Bobr, Aleh ;

Igyarto, Botond Z. ;

Haley, Krystal M. ;

Li, Ming O. ;

Flavell, Richard A. ;

Kaplan, Daniel H. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2012, 109 (26) :10492-10497

[7] Efficient targeting of protein antigen to the dendritic cell receptor DEC-205 in the steady state leads to antigen presentation on major histocompatibility complex class I products and peripheral CD8+ T cell tolerance [J].

Bonifaz, L ;

Bonnyay, D ;

Mahnke, K ;

Rivera, M ;

Nussenzweig, MC ;

Steinman, RM .

JOURNAL OF EXPERIMENTAL MEDICINE, 2002, 196 (12) :1627-1638

[8] In vivo targeting of antigens to maturing dendritic cells via the DEC-205 receptor improves T cell vaccination [J].

Bonifaz, LC ;

Bonnyay, DP ;

Charalambous, A ;

Darguste, DI ;

Fujii, SI ;

Soares, H ;

Brimnes, MK ;

Moltedo, B ;

Moran, TM ;

Steinman, RM .

JOURNAL OF EXPERIMENTAL MEDICINE, 2004, 199 (06) :815-824

[9] Micromolding for ceramic microneedle arrays [J].

Bystrova, S. ;

Luttge, R. .

MICROELECTRONIC ENGINEERING, 2011, 88 (08) :1681-1684

[10] The dendritic cell subtype-restricted C-type lectin Clec9A is a target for vaccine enhancement [J].

Caminschi, Irina ;

Proietto, Anna I. ;

Ahmet, Fatma ;

Kitsoulis, Susie ;

Teh, Joo Shin ;

Lo, Jennifer C. Y. ;

Rizzitelli, Alexandra ;

Wu, Li ;

Vremec, David ;

van Dommelen, Serani L. H. ;

Campbell, Ian K. ;

Maraskovsky, Eugene ;

Braley, Hal ;

Davey, Gayle M. ;

Mottram, Patricia ;

De Velde, Nicholas van ;

Jensen, Kent ;

Lew, Andrew M. ;

Wright, Mark D. ;

Heath, William R. ;

Shortman, Ken ;

Lahoud, Mireille H. .

BLOOD, 2008, 112 (08) :3264-3273

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