Comprehensive assessment of vascular health in patients; towards endothelium-guided therapy

被引：43

作者：

Frolow, Marzena ^{[1
,2
]}

Drozdz, Agata ^{[1
,3
]}

Kowalewska, Agata ^{[1
]}

Nizankowski, Rafal ^{[1
]}

Chlopicki, Stefan ^{[1
,4
]}

机构：

[1] Jagiellonian Univ, JCET, Krakow, Poland

[2] Jagiellonian Univ, Dept Angiol, Krakow, Poland

[3] Cracow Univ Technol, Fac Mech Engn, Krakow, Poland

[4] Jagiellonian Univ, Coll Med, Chair Pharmacol, Dept Expt Pharmacol, Krakow, Poland

来源：

PHARMACOLOGICAL REPORTS | 2015年 / 67卷 / 04期

关键词：

Endothelial dysfunction; Flow-mediated dilation; Peripheral artery tonometry; Artery stiffness; Multiparametric assessment; FLOW-MEDIATED DILATION; CORONARY-ARTERY-DISEASE; CARDIOVASCULAR RISK-FACTORS; COA REDUCTASE INHIBITORS; ANKLE-BRACHIAL INDEX; PULSE-WAVE VELOCITY; NONINVASIVE ASSESSMENT; CLINICAL-PRACTICE; PREDICTIVE-VALUE; HEART-DISEASE;

D O I：

10.1016/j.pharep.2015.05.010

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Endothelial function has diagnostic, prognostic and therapeutic significance. A number of non-invasive techniques were introduced for its assessment, including flow-mediated dilation (FMD), finger plethysmography (RE-PAT) and digital thermal monitoring (DTM). All these methods can be performed simultaneously. In addition, various methods for measuring arterial wall stiffness are available such as: pulse wave analysis (PWA), pulse wave velocity (PWV), pulse contour analysis (PCA) and carotid wall distensibility coefficient (DC). Finally, carotid intima-media thickness (cIMT) and ankle brachial index (ABI) are used as surrogate read-outs of atherosclerosis. Here, we briefly describe the advantages, limitations and interrelationships of various methods used for the assessment of endothelial function, arterial stiffness, and present the concept of an integrated evaluation of vascular health based on multiple methods. This strategy may be useful to stratify cardiovascular risk and represents a step towards multiparametric assessment of endothelium for effective endothelium-guided therapy in patients with cardiovascular diseases. (C) 2015 Published by Elsevier Sp. z o.o. on behalf of Institute of Pharmacology, Polish Academy of Sciences.

引用

页码：786 / 792

页数：7

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