Diagnosis of sarcoidosis

被引:59
作者
Costabel, Ulrich [1 ]
Ohshimo, Shinichiro [1 ]
Guzman, Josune [2 ]
机构
[1] Univ Duisburg Essen, Dept Pneumol Allergy, Fac Med, Ruhrlandklin, D-45239 Essen, Germany
[2] Ruhr Univ Bochum, Bochum, Germany
关键词
cardiac magnetic resonance imaging; diagnosis; Lofgren's syndrome; positron emission tomography; transbronchial ultrasound-guided needle aspiration;
D O I
10.1097/MCP.0b013e3283056a61
中图分类号
R56 [呼吸系及胸部疾病];
学科分类号
摘要
Purpose of review To describe the recent advances in the diagnostic procedures for sarcoidosis and explore future directions. Recent findings Novel imaging techniques have been explored in sarcoidosis, such as positron emission tomography using L-[3-F-18]-alpha-methyltyrosine, which is more specific for malignancy than F-18-fluorodeoxyglucose positron emission tomography. The combined modality of L-[3-F-18]-alpha-methyltyrosine-positron emission tomography with fluorodeoxyglucose-positron emission tomography could successfully discriminate sarcoidosis from malignancy. The finding of delayed enhancement in cardiac magnetic resonance imaging could identify cardiac involvement of sarcoidosis with higher sensitivity than echocardiography, thallium scintigraphy, and gallium scintigraphy. Endobronchial ultrasonograpy-guided transbronchial needle aspiration is a safe and useful tool for diagnosing sarcoidosis with a diagnostic accuracy, sensitivity and specificity of 85-93, 78-89, and 92-96%, respectively. Developments in genetics have demonstrated that 99% of the human leukocyte antigen DRB1*0301/DQB1*0201-positive patients with Lofgren's syndrome show a spontaneous remission, in contrast to only 55% of the human leukocyte antigen DRB1*0301/DQB1*0201-negative patients. These alleles could be novel promising factors for discriminating a prognosis in Lofgren's syndrome. Summary Recent development including novel imaging technique:3, novel biopsy procedures, and genetic analyses could be of value for the diagnosis of sarcoidosis.
引用
收藏
页码:455 / 461
页数:7
相关论文
共 65 条
  • [11] COSTABEL U, 2005, EUR RESP MON, V32, P259
  • [12] Costabel U, 2007, CLIN DERMATOL, V25, P303, DOI 10.1016/j.clindermatol.2007.03.008
  • [13] Association of fatigue with an acute phase response in sarcoidosis
    Drent, M
    Wirnsberger, RM
    de Vries, J
    van Dieijen-Visser, MP
    Wouters, EFM
    Schols, AMWJ
    [J]. EUROPEAN RESPIRATORY JOURNAL, 1999, 13 (04) : 718 - 722
  • [14] Diagnosing sarcoidosis using endosonography-guided fine-needle aspiration
    Fritscher-Ravens, A
    Sriram, PVJ
    Topalidis, T
    Hauber, HP
    Meyer, A
    Soehendra, N
    Pforte, A
    [J]. CHEST, 2000, 118 (04) : 928 - 935
  • [15] Utility of gallium-67 scintigraphy for evaluation of cardiac sarcoidosis with ventricular tachycardia
    Futamatsu, Hideki
    Suzuki, Jun-Ichi
    Adachi, Susumu
    Okada, Hiroyuki
    Otomo, Kenichiro
    Ohara, Takahiro
    Hashimoto, Yuji
    Kakuta, Tsunekazu
    Iesaka, Yoshito
    Yamaguchi, Hiroaki
    Sakurada, Harumizu
    Sato, Akira
    Obayashi, Tohru
    Niwa, Akihiro
    Hirao, Kenzo
    Isobe, Mitsuaki
    [J]. INTERNATIONAL JOURNAL OF CARDIOVASCULAR IMAGING, 2006, 22 (3-4) : 443 - 448
  • [16] Endobronchial ultrasound for the diagnosis of pulmonary sarcoidosis
    Garwood, Susan
    Judson, Marc A.
    Silvestri, Gerard
    Hoda, Rana
    Fraig, Mostafa
    Doelken, Peter
    [J]. CHEST, 2007, 132 (04) : 1298 - 1304
  • [17] TRANSBRONCHIAL LUNG-BIOPSY IN SARCOIDOSIS - AN APPROACH TO DETERMINE THE OPTIMAL NUMBER OF BIOPSIES
    GILMAN, MJ
    WANG, KP
    [J]. AMERICAN REVIEW OF RESPIRATORY DISEASE, 1980, 122 (05): : 721 - 724
  • [18] Mediastinoscopy vs thoracoscopy for mediastinal biopsy - Results of a prospective nonrandomized study
    Gossot, D
    Toledo, L
    Fritsch, S
    Celerier, M
    [J]. CHEST, 1996, 110 (05) : 1328 - 1331
  • [19] GRONHAGENRISKA C, 1979, SCAND J RESPIR DIS, V60, P83
  • [20] Human leukocyte antigen class I alleles and the disease course in sarcoidosis patients
    Grunewald, J
    Eklund, A
    Olerup, O
    [J]. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2004, 169 (06) : 696 - 702