Distribution of silver nanoparticles in pregnant mice and developing embryos

被引：89

作者：

Austin, Carlye A. ^{[2
]}

Umbreit, Thomas H.

Brown, Ken M. ^{[2
]}

Barber, David S. ^{[3
]}

Dair, Benita J.

Francke-Carroll, Sabine ^{[4
]}

Feswick, April ^{[3
]}

Saint-Louis, Melissa A. ^{[5
]}

Hikawa, Hiroyuki ^{[6
]}

Siebein, Kerry N. ^{[7
]}

Goering, Peter L. ^{[1
]}

机构：

[1] US FDA, Ctr Devices & Radiol Hlth, White Oak Life Sci Lab, Silver Spring, MD 20993 USA

[2] George Washington Univ, Dept Biol Sci, Washington, DC 20052 USA

[3] Univ Florida, Ctr Environm & Human Toxicol, Gainesville, FL USA

[4] US FDA, Ctr Food Safety & Nutr, College Pk, MD USA

[5] George Washington Univ, Reprod Endocrinol & Fertil Dept, Med Fac Associates, Washington, DC USA

[6] George Washington Univ, Dept Stat, Washington, DC 20052 USA

[7] Univ Florida, Dept Mat Sci & Engn, Gainesville, FL 32611 USA

来源：

NANOTOXICOLOGY | 2012年 / 6卷 / 08期

关键词：

Silver; nanoparticles; embryos; mice; in vivo; distribution; IN-VITRO; YOLK-SAC; TOXICITY; MOUSE; PARTICLES; PLACENTA; INCREASES; DRESSINGS; EXPOSURE; DAMAGE;

D O I：

10.3109/17435390.2011.626539

中图分类号：

TB3 [工程材料学];

学科分类号：

0805 ; 080502 ;

摘要：

The objective of this study was to evaluate the distribution of silver nanoparticles (NPs) in pregnant mice and their developing embryos. Silver NPs (average diameter 50 nm) were intravenously injected into pregnant CD-1 mice on gestation days (GDs) 7, 8, and 9 at dose levels of 0, 35, or 66 mu g Ag/mouse. Mice were euthanised on GD10, and tissue samples were collected and analysed for silver content. Compared with control animals injected with citrate buffer vehicle, silver content was significantly increased (p < 0.05) in nearly all tissues from silver NP-treated mice. Silver accumulation was significantly higher in liver, spleen, lung, tail (injection site), visceral yolk sac, and endometrium compared with other organs from silver NP-treated mice. Furthermore, silver NPs were identified in vesicles in endodermal cells of the visceral yolk sac. In summary, the results demonstrated that silver NPs distributed to most maternal organs, extra-embryonic tissues, and embryos, but did not accumulate significantly in embryos.

引用

页码：912 / 922

页数：11

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