Kaposi Sarcoma Risk in HIV-Infected Children and Adolescents on Combination Antiretroviral Therapy From Sub-Saharan Africa, Europe, and Asia

被引：16

作者：

Tanser, Frank ^{[2
]}

Vinikoor, Michael ^{[3
]}

Macete, Eusebio ^{[4
]}

Wood, Robin ^{[5
,6
]}

Stinson, Kathryn ^{[7
,8
]}

Garone, Daniela ^{[7
,8
]}

Fatti, Geoffrey ^{[9
]}

Phiri, Sam ^{[10
]}

Giddy, Janet ^{[11
]}

Chimbetete, Cleophas ^{[12
]}

Malisita, Kennedy ^{[13
,14
,15
]}

Eley, Brian

Fritz, Christiane ^{[16
]}

Hobbins, Michael ^{[17
]}

Kamenova, Kamelia ^{[18
]}

Fox, Matthew ^{[19
]}

Prozesky, Hans ^{[20
]}

Technau, Karl ^{[21
]}

Sawry, Shobna ^{[22
]}

Zangerle, Robert ^{[23
]}

Touloumi, Giota ^{[24
]}

Warszawski, Josiane ^{[25
]}

Meyer, LauRence ^{[26
]}

Dabis, Francois ^{[27
]}

Krause, Murielle Mary ^{[28
]}

Ghosn, Jade ^{[29
]}

Leport, Catherine ^{[30
]}

Wittkop, Linda ^{[31
]}

Reiss, Peter ^{[32
]}

Wit, Ferdinand ^{[32
]}

Prins, Maria ^{[33
]}

Bucher, Heiner ^{[33
]}

Sabin, Caroline ^{[34
]}

Gibb, Diana ^{[35
]}

Faetkenheuer, Gerd

Del Amo, Julia ^{[36
]}

Obel, Niels ^{[37
]}

Thorne, Claire ^{[38
]}

Mocroft, Amanda ^{[39
]}

Kirk, Ole ^{[39
]}

Stephan, Christoph

Perez-Hoyos, Santiago ^{[40
]}

Hamouda, Osamah ^{[41
]}

Bartmeyer, Barbara ^{[41
]}

Chkhartishvili, Nikoloz ^{[42
]}

Noguera-Julian, Antoni ^{[43
]}

Antinori, Andrea ^{[44
]}

Monforte, Antonella d'Arminio ^{[45
]}

Brockmeyer, Norbert ^{[46
]}

Prieto, Luis ^{[47
]}

机构：

[1] Univ Bern, Inst Social & Prevent Med, Finkenhubelweg 11, CH-3012 Bern, Switzerland

[2] Univ Kwazulu Natal, Africa Ctr Hlth & Populat Studies, Somkhele, South Africa

[3] Ctr Infect Dis Res Zambia, Lusaka, Zambia

[4] Ctr Invest Saude Manhica, Manhica, Mozambique

[5] Desmond Tutu HIV Ctr, Gugulethu Clin, Cape Town, South Africa

[6] Desmond Tutu HIV Ctr, Masiphumelele Clin, Cape Town, South Africa

[7] Khayelitsha ART Programme, Cape Town, South Africa

[8] Med Sans Frontieres, Cape Town, South Africa

[9] Kheth Impilo Programme, Cape Town, South Africa

[10] Lighthouse Trust Clin, Lilongwe, Malawi

[11] McCord Hosp, Durban, South Africa

[12] Newlands Clin, Harare, Zimbabwe

[13] Queen Elizabeth Hosp, Blantyre, Malawi

[14] Univ Cape Town, Red Cross War Mem Childrens Hosp, Cape Town, South Africa

[15] Univ Cape Town, Dept Paediat & Child Hlth, Cape Town, South Africa

[16] SolidarMed SMART Programme, Maseru, Lesotho

[17] SolidarMed SMART Programme, Pemba Region, Mozambique

[18] SolidarMed SMART Programme, Masvingo, Zimbabwe

[19] Themba Lethu Clin, Johannesburg, South Africa

[20] Tygerberg Acad Hosp, Cape Town, South Africa

[21] Rahima Moosa Mother & Child Hosp, Empilweni Clin, Johannesburg, South Africa

[22] Chris Hani Baragwanath Hosp, Harriet Shezi Childrens Clin, Soweto, South Africa

[23] AHIV COS, Soweto, South Africa

[24] AMACS, Houston, TX USA

[25] ANRS CO1 EPF ANRS CO11 OBSERV EPF, Houston, TX USA

[26] ANRS CO2 SEROCO, Houston, TX USA

[27] ANRS CO3 AQUITAINE, Houston, TX USA

[28] ANRS CO4 FHDH, Houston, TX USA

[29] ANRS CO6 PRIMO, Houston, TX USA

[30] ANRS CO8 COPILOTE, Houston, TX USA

[31] ANRS CO13 HEP AVIH, Houston, TX USA

[32] ATHENA, Houston, TX USA

[33] CASCADE, Fairview, OR USA

[34] UK CHIC, London, England

[35] CHIPS, London, England

[36] CoRIS, Paris, France

[37] Danish HIV Cohort, Paris, France

[38] ECS, Paris, France

[39] EuroSIDA, Paris, France

[40] GEMES Haemo, Paris, France

[41] German ClinSurv, Berlin, Germany

[42] Georgian Natl HIV AIDS, Berlin, Germany

[43] CORISPE Cat, Catalonia, Spain

[44] ICC, Catalonia, Spain

[45] ICONA, Catalonia, Spain

[46] KOMPNET, Torun, Poland

[47] Madrid PMTCT Cohort, Torun, Poland

[48] CORISPES Madrid, Madrid, Spain

[49] NENEXP, Madrid, Spain

[50] SHCS, Madrid, Spain

来源：

CLINICAL INFECTIOUS DISEASES | 2016年 / 63卷 / 09期

基金：

瑞士国家科学基金会; 美国国家卫生研究院;

关键词：

Kaposi sarcoma; HIV; children; antiretroviral therapy; cohort study; COHORT PROFILE; CANCER; AIDS; HERPESVIRUS; TERM; IMMUNODEFICIENCY; SEROPREVALENCE; MALIGNANCIES;

D O I：

10.1093/cid/ciw519

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Background. The burden of Kaposi sarcoma (KS) in human immunodeficiency virus (HIV)-infected children and adolescents on combination antiretroviral therapy (cART) has not been compared globally. Methods. We analyzed cohort data from the International Epidemiologic Databases to Evaluate AIDS and the Collaboration of Observational HIV Epidemiological Research in Europe. We included HIV-infected children aged <16 years at cART initiation from 1996 onward. We used Cox models to calculate hazard ratios (HRs), adjusted for region and origin, sex, cART start year, age, and HIV/AIDS stage at cART initiation. Results. We included 24 991 children from eastern Africa, southern Africa, Europe and Asia; 26 developed KS after starting cART. Incidence rates per 100 000 person-years (PYs) were 86 in eastern Africa (95% confidence interval [CI], 55-133), 11 in southern Africa (95% CI, 4-35), and 81 (95% CI, 26-252) in children of sub-Saharan African (SSA) origin in Europe. The KS incidence rates were 0/100 000 PYs in children of non-SSA origin in Europe (95% CI, 0-50) and in Asia (95% CI, 0-27). KS risk was lower in girls than in boys (adjusted HR [aHR], 0.3; 95% CI, .1-. 9) and increased with age (10-15 vs 0-4 years; aHR, 3.4; 95% CI, 1.2-10.1) and advanced HIV/AIDS stage (CDC stage C vs A/B; aHR, 2.4; 95% CI,.8-7.3) at cART initiation. Conclusions. HIV-infected children from SSA but not those from other regions, have a high risk of developing KS after cART initiation. Early cART initiation in these children might reduce KS risk.

引用

页码：1245 / 1253

页数：9

共 50 条

[1] Incidence Rate of Kaposi Sarcoma in HIV-Infected Patients on Antiretroviral Therapy in Southern Africa: A Prospective Multicohort Study
Rohner, Eliane
Valeri, Fabio
Maskew, Mhairi
Prozesky, Hans
Rabie, Helena
Garone, Daniela
Dickinson, Diana
Chimbetete, Cleophas
Lumano-Mulenga, Priscilla
Sikazwe, Izukanji
Wyss, Natascha
Clough-Gorr, Kerri M.
Egger, Matthias
Chi, Benjamin H.
Bohlius, Julia
JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES, 2014, 67 (05) : 547 - 554
[2] Endoscopy Findings in HIV-Infected Children from Sub-Saharan Africa
Cooke, M. L.
Goddard, E. A.
Brown, R. A.
JOURNAL OF TROPICAL PEDIATRICS, 2009, 55 (04) : 238 - 243
[3] Effect of cotrimoxazole prophylaxis on malaria occurrence in HIV-infected patients on antiretroviral therapy in sub-Saharan Africa
Kasirye, R.
Baisley, K.
Munderi, P.
Grosskurth, H.
TROPICAL MEDICINE & INTERNATIONAL HEALTH, 2015, 20 (05) : 569 - 580
[4] How disclosure and antiretroviral therapy help HIV-infected adolescents in sub-Saharan Africa cope with stigma
Midtbo, Vivian
Shirima, Violeth
Skovdal, Morten
Daniel, Marguerite
AJAR-AFRICAN JOURNAL OF AIDS RESEARCH, 2012, 11 (03): : 261 - 271
[5] Kaposi's Sarcoma in HIV-infected patients in South Africa: Multicohort study in the antiretroviral therapy era
Bohlius, Julia
Valeri, Fabio
Maskew, Mhairi
Prozesky, Hans
Garone, Daniela
Sengayi, Mazvita
Fox, Matthew P.
Davies, Mary-Ann
Egger, Matthias
INTERNATIONAL JOURNAL OF CANCER, 2014, 135 (11) : 2644 - 2652
[6] Interventions to reduce mortality in sub-Saharan Africa among HIV-infected adults not yet on antiretroviral therapy
Peterson, Kevin
van Griensven, Johan
in 't Veld, Diana Huis
Colebunders, Robert
EXPERT REVIEW OF ANTI-INFECTIVE THERAPY, 2012, 10 (01) : 43 - 50
[7] Contemporary issues on the epidemiology and antiretroviral adherence of HIV-infected adolescents in sub-Saharan Africa: a narrative review
Adejumo, Olurotimi A.
Malee, Kathleen M.
Ryscavage, Patrick
Hunter, Scott J.
Taiwo, Babafemi O.
JOURNAL OF THE INTERNATIONAL AIDS SOCIETY, 2015, 18
[8] The challenges of timely and safe HIV disclosure among perinatally HIV-infected adolescents in sub-Saharan Africa
Dahourou, Desire
Raynaud, Jean-Philippe
Leroy, Valeriane
CURRENT OPINION IN HIV AND AIDS, 2018, 13 (03) : 220 - 229
[9] Improved Adherence to Antiretroviral Therapy Observed Among HIV-Infected Children Whose Caregivers had Positive Beliefs in Medicine in Sub-Saharan Africa
G. Abongomera
A. Cook
V. Musiime
C. Chabala
M. Lamorde
J. Abach
M. Thomason
V. Mulenga
A. Kekitiinwa
R. Colebunders
C. Kityo
A. S. Walker
D. M. Gibb
AIDS and Behavior, 2017, 21 : 441 - 449
[10] Differentiated HIV care in sub-Saharan Africa: a scoping review to inform antiretroviral therapy provision for stable HIV-infected individuals in Kenya
Hagey, Jill M.
Li, Xuan
Barr-Walker, Jill
Penner, Jeremy
Kadima, Julie
Oyaro, Patrick
Cohen, Craig R.
AIDS CARE-PSYCHOLOGICAL AND SOCIO-MEDICAL ASPECTS OF AIDS/HIV, 2018, 30 (12): : 1477 - 1487

← 1 2 3 4 5 →