Cancer cell metabolism: Warburg and beyond

被引：1960

作者：

Hsu, Peggy P. ^{[1
,2
,3
]}

Sabatini, David M. ^{[1
,2
,3
,4
]}

机构：

[1] Whitehead Inst Biomed Res, Cambridge, MA 02142 USA

[2] MIT, Dept Biol, Cambridge, MA 02142 USA

[3] Broad Inst, Cambridge, MA 02142 USA

[4] MIT, Koch Inst Integrat Canc Res, Cambridge, MA 02139 USA

来源：

CELL | 2008年 / 134卷 / 05期

关键词：

D O I：

10.1016/j.cell.2008.08.021

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Described decades ago, the Warburg effect of aerobic glycolysis is a key metabolic hallmark of cancer, yet its significance remains unclear. In this Essay, we re-examine the Warburg effect and establish a framework for understanding its contribution to the altered metabolism of cancer cells.

引用

页码：703 / 707

页数：5

共 41 条

[1] TIGAR, a p53-inducible regulator of glycolysis and apoptosis [J].

Bensaad, Karim ;

Tsuruta, Atsushi ;

Selak, Mary A. ;

Calvo Vidal, M. Nieves ;

Nakano, Katsunori ;

Bartrons, Ramon ;

Gottlieb, Eyal ;

Vousden, Karen H. .

CELL, 2006, 126 (01) :107-120

[2] A mitochondria-K+ channel axis is suppressed in cancer and its normalization promotes apoptosis and inhibits cancer growth [J].

Bonnet, Sebastien ;

Archer, Stephen L. ;

Allalunis-Turner, Joan ;

Haromy, Alois ;

Beaulieu, Christian ;

Thompson, Richard ;

Lee, Christopher T. ;

Lopaschuk, Gary D. ;

Puttagunta, Lakshmi ;

Bonnet, Sandra ;

Harry, Gwyneth ;

Hashimoto, Kyoko ;

Porter, Christopher J. ;

Andrade, Miguel A. ;

Thebaud, Bernard ;

Michelakis, Evangelos D. .

CANCER CELL, 2007, 11 (01) :37-51

[3] The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth [J].

Christofk, Heather R. ;

Vander Heiden, Matthew G. ;

Harris, Marian H. ;

Ramanathan, Arvind ;

Gerszten, Robert E. ;

Wei, Ru ;

Fleming, Mark D. ;

Schreiber, Stuart L. ;

Cantley, Lewis C. .

NATURE, 2008, 452 (7184) :230-U74

[4] Pyruvate kinase M2 is a phosphotyrosine-binding protein [J].

Christofk, Heather R. ;

Vander Heiden, Matthew G. ;

Wu, Ning ;

Asara, John M. ;

Cantley, Lewis C. .

NATURE, 2008, 452 (7184) :181-U27

[5] GAPDH and autophagy preserve survival after apoptotic cytochrome c release in the absence of caspase activation [J].

Colell, Anna ;

Ricci, Jean-Ehrland ;

Tait, Stephen ;

Milasta, Sandra ;

Maurer, Ulrich ;

Bouchier-Hayes, Lisa ;

Fitzgerald, Patrick ;

Guio-Carrion, Ana ;

Waterhouse, Nigel J. ;

Li, Cindy Wei ;

Mari, Bernard ;

Barbry, Pascal ;

Newmeyer, Donald D. ;

Beere, Helen M. ;

Green, Douglas R. .

CELL, 2007, 129 (05) :983-997

[6] Oncogenic alterations of metabolism [J].

Dang, CV ;

Semenza, GL .

TRENDS IN BIOCHEMICAL SCIENCES, 1999, 24 (02) :68-72

[7] Beyond aerobic glycolysis: Transformed cells can engage in glutamine metabolism that exceeds the requirement for protein and nucleotide synthesis [J].

DeBerardinis, Ralph J. ;

Mancuso, Anthony ;

Daikhin, Evgueni ;

Nissim, Ilana ;

Yudkoff, Marc ;

Wehrli, Suzanne ;

Thompson, Craig B. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2007, 104 (49) :19345-19350

[8] Targeting vacuolar H+-ATPases as a new strategy against cancer [J].

Fais, Stefano ;

De Milito, Angelo ;

You, Haiyan ;

Qin, Wenxin .

CANCER RESEARCH, 2007, 67 (22) :10627-10630

[9] The H+-linked monocarboxylate transporter (MCT1/SLC16A1):: A potential therapeutic target for high-risk neuroblastoma [J].

Fang, Jun ;

Quinones, Quintin J. ;

Holman, Trevor L. ;

Morowitz, Michael J. ;

Wang, Qun ;

Zhao, Huaqing ;

Sivo, Frank ;

Maris, John M. ;

Wahl, Miriam L. .

MOLECULAR PHARMACOLOGY, 2006, 70 (06) :2108-2115

[10] Attenuation of LDH-A expression uncovers a link between glycolysis, mitochondrial physiology, and tumor maintenance [J].

Fantin, Valeria R. ;

St-Pierre, Julie ;

Leder, Philip .

CANCER CELL, 2006, 9 (06) :425-434

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