Synthesis, Characterization and Antitumor Activity in Vitro of Cd(III) Complex with Chelidamic Acid

A novel complex [Cd-4(HCAM)(4)(H2O)(8)] of Cd(III) with chelidamic acid (H(3)CAM) was synthesized by the hydrothermal method and characterized with IR and emission spectra. The crystal structure was determined based on single-crystal X-ray diffraction data. It crystallizes in monoclinic, space group C2/c with a = 17.538(5), b = 12.916(4), c = 16.505(7) angstrom, beta = 100.690(14)degrees, V = 3674(2) angstrom(3), Z = 8, C14H14Cd2N2O14, M-r = 659.07, D-c = 2.383 g/cm(3) mu = 2.400 mm(-1), S = 1.000, F(000) = 2560, the final R = 0.0242 and wR = 0.0581 for 3656 observed reflections with I > 2 sigma(I). The inhibition of the complex against K562 and HL60 cells was determined by MTT assay. The results showed that the concentration of complex was positively correlated with inhibitions against K562 and HL60 cell lines, but inhibitory effects are relatively weak. IC50 concentration of the title complex on K562 and HL60 cells is 15 and 5 mu g/mL, respectively.