Renal tubular toxicity associated with tenofovir assessed using urine-beta 2 microglobulin, percentage of tubular reabsorption of phosphate and alkaline phosphatase levels

被引：40

作者：

Kinai, E ^{[1
]}

Hanabusa, H ^{[1
]}

机构：

[1] Ogikubo Hosp, Dept Hematol, Tokyo, Japan

来源：

AIDS | 2005年 / 19卷 / 17期

关键词：

D O I：

10.1097/01.aids.0000194130.05264.83

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Despite its wide use, the renal tubular toxicity of tenofovir has not been fully evaluated. Twelve weeks after initiating a tenofovir-containing HAART regimen, a high urine-beta 2 microglobulin level was observed in 12 out of 17 patients, the percentage of tubular reabsorption of phosphate decreased from 96.0 to 91.1% and alkaline phosphatase increased from 294 to 365 U/l, whereas serum creatinine and phosphorus remained largely unchanged. Patients with the above findings should be monitored carefully for renal tubular toxicity.

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页码：2031 / 2033

页数：3

相关论文

共 19 条

[1] Tenofovir-related nephrotoxicity in HIV-infected patients [J].

Barrios, A ;

García-Benayas, T ;

González-Lahoz, J ;

Soriano, V .

AIDS, 2004, 18 (06) :960-963

[2] Assessment of mitochondrial toxicity in human cells treated with tenofovir: Comparison with other nucleoside reverse transcriptase inhibitors [J].

Birkus, G ;

Hitchcock, MJM ;

Cihlar, T .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2002, 46 (03) :716-723

[3] Human renal organic anion transporter 1 (hOAT1) and its role in the nephrotoxicity of antiviral nucleotide analogs [J].

Cihlar, T ;

Ho, ES ;

Lin, DC ;

Mulato, AS .

NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS, 2001, 20 (4-7) :641-648

[4]

Day SL, 2005, JAIDS-J ACQ IMM DEF, V38, P301

[5] Efficacy and safety of tenofovir DF vs stavuldine in combination therapy in antiretroviral-naive patients - A 3-year randomized trial [J].

Gallant, JE ;

Staszewski, S ;

Pozniak, AL ;

DeJesus, E ;

Suleiman, JMAH ;

Miller, MD ;

Coakley, DF ;

Lu, B ;

Toole, JJ ;

Cheng, AK .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2004, 292 (02) :191-201

[6] Fanconi syndrome and acute renal failure in a patient treated with tenofovir:: a call for caution [J].

Gaspar, G ;

Monereo, A ;

García-Reyne, A ;

de Guzm n, M .

AIDS, 2004, 18 (02) :351-352

[7] Low molecular weight proteinuria in human immunodeficiency virus-infected patients [J].

Kabanda, A ;

Vandercam, B ;

Bernard, A ;

Lauwerys, R ;

deStrihou, CV .

AMERICAN JOURNAL OF KIDNEY DISEASES, 1996, 27 (06) :803-808

[8] Tenofovir-related nephrotoxicity in human immunodeficiency virus-infected patients: Three cases of renal failure, Fanconi syndrome, and nephrogenic diabetes insipidus [J].

Karras, A ;

Lafaurie, M ;

Furco, A ;

Bourgarit, A ;

Droz, D ;

Sereni, D ;

Legendre, C ;

Martinez, F ;

Molina, JM .

CLINICAL INFECTIOUS DISEASES, 2003, 36 (08) :1070-1073

[9] PATHOPHYSIOLOGY OF CALCIUM-METABOLISM IN CHILDREN WITH VITAMIN-D-DEFICIENCY RICKETS [J].

KRUSE, K .

JOURNAL OF PEDIATRICS, 1995, 126 (05) :736-741

[10] Fatal lactic acidosis and acute renal failure after addition of tenofovir to an Antiretroviral regimen containing Didanosine [J].

Murphy, MD ;

O'Hearn, M ;

Chou, SW .

CLINICAL INFECTIOUS DISEASES, 2003, 36 (08) :1082-1085