Kisspeptin is providing new insights into the control of reproduction

被引：2
作者：
Izzi-Engbeaya, Chioma [1 ,2 ]
Meeran, Karim [1 ,2 ]
Dhillo, Waljit S. [1 ,2 ]
机构：
[1] Univ London Imperial Coll Sci Technol & Med, Hammersmith Hosp, Sect Investigat Med, London W12 0NN, England
[2] Univ London Imperial Coll Sci Technol & Med, Charing Cross Hosp, Healthcare NHS Trust, Dept Endocrinol, London, England
来源：
CLINICAL MEDICINE | 2013年 / 13卷 / 06期
基金：
美国国家卫生研究院;
关键词：
Kisspeptin; reproduction; COUPLED RECEPTOR GPR54; HYPOGONADOTROPIC HYPOGONADISM; MUTATION; PUBERTY; GENE;
D O I：
10.7861/clinmedicine.13-6-547
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
The kisspeptins are a group of recently discovered peptide hormones (collectively termed kisspeptin), which play a pivotal role in reproduction. Research investigating the actions of kisspeptin is helping to elucidate the regulatory mechanisms which govern fertility and may lead to the development of novel treatments for some reproductive disorders.
引用
收藏
页码：547 / 548
页数：2
相关论文
共 11 条
[1]   FMRFamide-related neuropeptides are agonists of the orphan G-protein-coupled receptor GPR54 [J].
Clements, MK ;
McDonald, TP ;
Wang, RP ;
Xie, GC ;
O'Dowd, BF ;
George, SR ;
Austin, CP ;
Liu, QY .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2001, 284 (05) :1189-1193
[2]   Hypogonadotropic hypogonadism due to loss of function of the KiSS1-derived peptide receptor GPR54 [J].
de Roux, N ;
Genin, E ;
Carel, JC ;
Matsuda, F ;
Chaussain, JL ;
Milgrom, E .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (19) :10972-10976
[3]   Kisspeptin-54 stimulates gonadotropin release most potently during the Preovulatory phase of the menstrual cycle in women [J].
Dhillo, Waljit S. ;
Chaudhri, Owais B. ;
Thompson, Emily L. ;
Murphy, Kevin G. ;
Patterson, Michael ;
Ramachandran, Radha ;
Nijher, Gurjinder K. ;
Amber, Vian ;
Kokkinos, Alexander ;
Donaldson, Mandy ;
Ghatei, Mohammad A. ;
Bloom, Stephen R. .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2007, 92 (10) :3958-3966
[4]   Kisspeptin-54 stimulates the hypothalamic-pituitary gonadal axis in human males [J].
Dhillo, WS ;
Chaudhri, OB ;
Patterson, M ;
Thompson, EL ;
Murphy, KG ;
Badman, MK ;
McGowan, BM ;
Amber, V ;
Patel, S ;
Ghatei, MA ;
Bloom, SR .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2005, 90 (12) :6609-6615
[5]   Kisspeptin and fertility [J].
Hameed, Saira ;
Jayasena, Channa N. ;
Dhillo, Waljit S. .
JOURNAL OF ENDOCRINOLOGY, 2011, 208 (02) :97-105
[6]   Subcutaneous Injection of Kisspeptin-54 Acutely Stimulates Gonadotropin Secretion in Women with Hypothalamic Amenorrhea, But Chronic Administration Causes Tachyphylaxis [J].
Jayasena, Channa N. ;
Nijher, Gurjinder M. K. ;
Chaudhri, Owais B. ;
Murphy, Kevin G. ;
Ranger, Amita ;
Lim, Adrian ;
Patel, Daksha ;
Mehta, Amrish ;
Todd, Catriona ;
Ramachandran, Radha ;
Salem, Victoria ;
Stamp, Gordon W. ;
Donaldson, Mandy ;
Ghatei, Mohammad A. ;
Bloom, Stephen R. ;
Dhillo, Waljit S. .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2009, 94 (11) :4315-4323
[7]   The metastasis suppressor gene KiSS-1 encodes kisspeptins, the natural ligands of the orphan G protein-coupled receptor GPR54 [J].
Kotani, M ;
Detheux, M ;
Vandenbbogaerde, A ;
Communi, D ;
Vanderwinden, JM ;
Le Poul, E ;
Brézillon, S ;
Tyldesley, R ;
Suarez-Huerta, N ;
Vandeput, F ;
Blanpain, C ;
Schiffmann, SN ;
Vassart, G ;
Parmentier, M .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (37) :34631-34636
[8]   The GPR54 gene as a regulator of puberty [J].
Seminara, SB ;
Messager, S ;
Chatzidaki, EE ;
Thresher, RR ;
Acierno, JS ;
Shagoury, JK ;
Bo-Abbas, Y ;
Kuohung, W ;
Schwinof, KM ;
Hendrick, AG ;
Zahn, D ;
Dixon, J ;
Kaiser, UB ;
Slaugenhaupt, SA ;
Gusella, JF ;
O'Rahilly, S ;
Carlton, MBL ;
Crowley, WF ;
Aparicio, SAJR ;
Colledge, WH .
NEW ENGLAND JOURNAL OF MEDICINE, 2003, 349 (17) :1614-U8
[9]   Hyperprolactinemia-induced ovarian acyclicity is reversed by kisspeptin administration [J].
Sonigo, Charlotte ;
Bouilly, Justine ;
Carre, Nadege ;
Tolle, Virginie ;
Caraty, Alain ;
Tello, Javier ;
Simony-Conesa, Fabian-Jesus ;
Millar, Robert ;
Young, Jacques ;
Binart, Nadine .
JOURNAL OF CLINICAL INVESTIGATION, 2012, 122 (10) :3791-3795
[10]   A GPR54-activating mutation in a patient with central precocious puberty [J].
Teles, Milena Gurgel ;
Bianco, Suzy D. C. ;
Brito, Vinicius Nahime ;
Trarbach, Ericka B. ;
Kuohung, Wendy ;
Xu, Shuyun ;
Seminara, Stephanie B. ;
Mendonca, Berenice B. ;
Kaiser, Ursula B. ;
Latronico, Ana Claudia .
NEW ENGLAND JOURNAL OF MEDICINE, 2008, 358 (07) :709-715
12