Pentacyclic triterpenes. Part 3: Synthesis and biological evaluation of oleanolic acid derivatives as novel inhibitors of glycogen phosphorylase

被引：103

作者：

Chen, J

Liu, J

Zhang, LY

Wu, GZ

Hua, WY

Wu, XM

Sun, HB

机构：

[1] China Pharmaceut Univ, Coll Pharm, Ctr Drug Discovery, Nanjing 210009, Peoples R China

[2] China Pharmaceut Univ, Jiangsu Ctr Drug Screening, Nanjing 210038, Peoples R China

[3] China Pharmaceut Univ, Coll Pharm, Dept Pharmacol, Nanjing 210009, Peoples R China

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2006年 / 16卷 / 11期

关键词：

oleanolic acid; glycogen phosphorylase; inhibitor; derivatives; diabetes;

D O I：

10.1016/j.bmcl.2006.03.009

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Oleanolic acid and its synthetic derivatives have been identified as novel inhibitors of glycogen phosphorylase. Within this series of compounds, 4 (IC50 = 3.3 mu M) is the most potent GPa inhibitor. Preliminary structure-activity relationships of the oleanolic acid derivatives are discussed. (c) 2006 Elsevier Ltd. All rights reserved.

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收藏

页码：2915 / 2919

页数：5

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