Clinical effectiveness of tumor markers in squamous cell carcinoma of the larynx

被引：0
作者：
Eleftheriadou, Anna
Chalastras, Thomas
Ferekidou, Elisa
Kyriou, Lambrini
Yiotakis, Ioannis
Pappas, Zisis
Ferekidis, Eleftherios
Kandiloros, Dimitrios
机构：
[1] G Gennimatas Hosp, Dept Otolaryngol, Athens, Greece
[2] Evangelismos Med Ctr, Dept Biochem, Athens, Greece
[3] Univ Athens, Dept Otolaryngol, Ippokrat Hosp, Athens, Greece
来源：
ANTICANCER RESEARCH | 2006年 / 26卷 / 3B期
关键词：
SCC of the larynx; tumor markers; CYFRA; 21-1; TPA-M; SCCA; CEA;
D O I：
暂无
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Background: The aim of this study was to examine and compare the value of the serum tumor markers CYFRA 21-1, TPA-M, SCCA and CEA in squamous cell carcinoma (SCC) of the larynx. Moreover, their possible clinical applications were studied. Materials and Methods: The serum levels of CYFRA 21-1, TPA-M, SCCA and CFA were measured in 79 patients with histologically proven squamous cell carcinoma (SCC) of the larynx before and after treatment and in 77 healthy volunteers. The association of the results with the clinicopathological characteristics was investigated. Results: The study showed that none of the markers revealed a significant sensitivity; TPA-M indicated a positive correlation with the grade of differentiation. CEA indicated a positive correlation only with distant metastasis. Conclusion: Among the four markers, only TPA-M may play a role in monitoring the success of therapy and follow-up inpatients with SCC of the larynx.
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收藏
页码：2493 / 2497
页数：5
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