Adult parameningial alveolar rhabdomyosarcoma: Case report and literature review

被引:2
作者
Barthere, Xavier [1 ]
Guillerm, Sophie [1 ]
Quero, Laurent [1 ]
Le Maignan, Christine [2 ]
Torossian, Nourezza [2 ]
Verillaud, Benjamin [3 ]
Itti, Ramona [1 ]
Hennequin, Christophe [1 ]
机构
[1] Univ Paris VII, Radiat Oncol Dept, Grp Hosp St Louis Lariboisiere, AP HP, F-75475 Paris, France
[2] Univ Paris VII, Med Oncol Dept, Grp Hosp St Louis Lariboisiere, AP HP, F-75475 Paris, France
[3] Univ Paris VII, Head & Neck Surg, Grp Hosp St Louis Lariboisiere, AP HP, F-75475 Paris, France
来源
CANCER RADIOTHERAPIE | 2020年 / 24卷 / 08期
关键词
Alveolar rhabdomyosarcoma; Chemotherapy; Radiation therapy; Adult; NECK RHABDOMYOSARCOMA; AMORE PROTOCOL; CHILDREN; HEAD; RADIOTHERAPY; IV; SARCOMA; TRIAL;
D O I
10.1016/j.canrad.2020.03.015
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Alveolar rhabdomyosarcoma (ARMS) represents the most common childhood soft tissue sarcoma, but they are rarely seen among adults. Most of the protocols for adults are adapted from pediatric protocols. Here we report a case of a 53-year-old woman diagnosed with a nasal alveolar rhabdomyosarcoma, stage IV at diagnosis, treated by chemotherapy (a regimen inspired from the pediatric protocole pEpSSG RMS 2005) which led to partial response followed by chemo-radiotherapy. We performed a systematic review of adult head and neck ARMS and found 29 cases. Primary chemotherapy with different protocols (VAC, VAI or VIE) should be done followed by surgery and/or external beam radiotherapy (preferably with IMRT). EBRT seems beneficial to every ARMS with a dose around 50 Gy in a conventional fractionation, eventually completed with a boost on residual tumor. The target volume must be defined on pre-chemotherapy imaging. Brachytherapy and proton therapy are under evaluation. (C) 2020 Published by Elsevier Masson SAS on behalf of Societe francaise de radiotherapie oncologique (SFRO).
引用
收藏
页码:870 / 875
页数:6
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