RETRACTED: Exosome circRNA secreted from adipocytes promotes the growth of hepatocellular carcinoma by targeting deubiquitination-related USP7 (Retracted Article)

被引：296

作者：

Zhang, Haiyang ^{[1
]}

Deng, Ting ^{[1
]}

Ge, Shaohua ^{[1
]}

Liu, Ying ^{[1
]}

Bai, Ming ^{[1
]}

Zhu, Kegan ^{[1
]}

Fan, Qian ^{[1
]}

Li, Jialu ^{[2
,3
]}

Ning, Tao ^{[1
]}

Tian, Fei ^{[1
]}

Li, Hongli ^{[1
]}

Sun, Wu ^{[1
]}

Ying, Guoguang ^{[1
]}

Ba, Yi ^{[1
]}

机构：

[1] Tianjin Med Univ, Natl Clin Res Ctr Canc, Key Lab Canc Prevent & Therapy, Canc Inst & Hosp,Tianjins Clin Res Ctr Canc, Tianjin 300060, Peoples R China

[2] Shanghai Jiao Tong Univ, Div Gastroenterol & Hepatol, Shanghai Inst Digest Dis, Sch Med,Renji Hosp, Shanghai 200001, Peoples R China

[3] Shanghai Jiao Tong Univ, Key Lab Gastroenterol & Hepatol, Minist Hlth, Sch Med,Renji Hosp, Shanghai 200001, Peoples R China

来源：

ONCOGENE | 2019年 / 38卷 / 15期

基金：

中国国家自然科学基金;

关键词：

CELL-PROLIFERATION; CIRCULAR RNAS; BETA-CATENIN; CANCER; STABILIZATION; BIOGENESIS; DELIVERY; PROTEIN;

D O I：

10.1038/s41388-018-0619-z

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Hepatocellular carcinoma (HCC), the major form of liver cancer, has shown increasing incidence and poor prognosis. Adipose tissue is known to function in energy storage and metabolism regulation by the secretion of adipokines. Circular RNAs (circRNAs), a novel type of noncoding RNA, have recently been recognized as key factors in tumor development, but the role of exosome circRNAs derived from adipose tissues has not been defined yet. Here, adipose-secreted circRNAs were found to regulate deubiquitination in HCC, thus facilitating cell growth. It was observed that exosome circ-deubiquitination (circ-DB) is upregulated in HCC patients with higher body fat ratios. Moreover, in vitro and in vivo studies showed that exocirc-DB promotes HCC growth and reduces DNA damage via the suppression of miR-34a and the activation of deubiquitination-related USP7. Finally, the results showed that the effects of adipose exosomes on HCC cells can be reversed by knockdown of circ-DB. These results indicate that exosome circRNAs secreted from adipocytes promote tumor growth and reduce DNA damage by suppressing miR-34a and activating the USP7/Cyclin A2 signaling pathway.

引用

页码：2844 / 2859

页数：16

共 39 条

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