COVID-19 and the Heart and Vasculature Novel Approaches to Reduce Virus-Induced Inflammation in Patients With Cardiovascular Disease

被引：24

作者：

Kadosh, Bernard S. ^{[1
]}

Garshick, Michael S. ^{[1
]}

Gaztanaga, Juan ^{[3
]}

Moore, Kathryn J. ^{[1
]}

Newman, Jonathan D. ^{[1
]}

Pillinger, Michael ^{[2
,4
]}

Ramasamy, Ravichandran ^{[1
]}

Reynolds, Harmony R. ^{[1
]}

Shah, Binita ^{[4
]}

Hochman, Judith ^{[1
]}

Fishman, Glenn, I ^{[1
]}

Katz, Stuart D. ^{[1
]}

机构：

[1] NYU, Dept Med, Leon H Charney Div Cardiol, Grossman Sch Med, 550 1St Ave, New York, NY 10016 USA

[2] Dept Med, Div Rheumatol, New York, NY USA

[3] NYU, Dept Cardiol, Winthrop Hosp, Div Internal Med, Mineola, NY USA

[4] VA New York Harbor Healthcare Syst, Dept Med, New York, NY USA

来源：

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY | 2020年 / 40卷 / 09期

基金：

美国国家卫生研究院;

关键词：

inflammation; morbidity; mortality; pandemics; viruses; C-REACTIVE PROTEIN; ALDOSE REDUCTASE; NLRP3; INFLAMMASOME; CLINICAL CHARACTERISTICS; SGLT2; INHIBITORS; OXIDATIVE STRESS; IL-1; FAMILY; ACTIVATION; OUTCOMES; COLCHICINE;

D O I：

10.1161/ATVBAHA.120.314513

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The coronavirus disease 2019 (COVID-19) pandemic presents an unprecedented challenge and opportunity for translational investigators to rapidly develop safe and effective therapeutic interventions. Greater risk of severe disease in COVID-19 patients with comorbid diabetes mellitus, obesity, and heart disease may be attributable to synergistic activation of vascular inflammation pathways associated with both COVID-19 and cardiometabolic disease. This mechanistic link provides a scientific framework for translational studies of drugs developed for treatment of cardiometabolic disease as novel therapeutic interventions to mitigate inflammation and improve outcomes in patients with COVID-19.

引用

页码：2045 / 2053

页数：9

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