HPLC-APCI-MS for the determination of vitamin K1 in human plasma: Method and clinical application

被引：34

作者：

Song, Qinxin ^{[1
]}

Wen, Aidong ^{[2
]}

Ding, Li ^{[1
]}

Dai, Li ^{[1
]}

Yang, Lin ^{[2
]}

Qi, Xiemin ^{[1
]}

机构：

[1] China Pharmaceut Univ, Dept Pharmaceut Anal, Nanjing 210009, Peoples R China

[2] Fourth Mil Med Univ, Xijing Hosp, Xian 710032, Peoples R China

来源：

JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES | 2008年 / 875卷 / 02期

关键词：

Vitamin K(1); HPLC-APCI-MS; Teprenone; Pharmacokinetics;

D O I：

10.1016/j.jchromb.2008.10.009

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

A sensitive HPLC-APCI-MS method for the determination of vitamin K, (VK-1) in human plasma was established. Target ions at [M+H](+) m/z 451.5 for VK-1 and [M+H](+) m/z 331.4 for the I.S. (teprenone). Calibration curve was linear over the range of 0.3-1000 ng/ml. The lower limit of quantification was 0.3 ng/ml. The intra- and inter-batch variability values were less than 8% and 15%, respectively. The C(max) was 210.1 +/- 86.7ng/ml while the elimination half-life (t(1/2)) was 8.8 +/- 1.7h and time to the C(max) was 5.5 +/- 0.8h after administration Of Soft Capsule containing Wing VK-1. (c) 2008 Elsevier B.V. All rights reserved.

引用

页码：541 / 545

页数：5

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