Synthesis of 2-(1H-Indol-2-yl)acetamides via Bronsted Acid-Assisted Cyclization Cascade

被引：15
|
作者：
Aksenov, Nicolai A. [1 ]
Aksenov, Dmitrii A. [1 ]
Skomorokhov, Anton A. [1 ]
Prityko, Lidiya A. [1 ]
Aksenov, Alexander V. [1 ]
Griaznov, Georgii D. [2 ]
Rubin, Michael [1 ,2 ]
机构：
[1] North Caucasus Fed Univ, Dept Chem, Stavropol 355009, Russia
[2] Univ Kansas, Dept Chem, Lawrence, KS 66045 USA
来源：
JOURNAL OF ORGANIC CHEMISTRY | 2020年 / 85卷 / 19期
基金：
俄罗斯科学基金会;
关键词：
INHIBITORY-ACTIVITY; MICHAEL ADDITION; HISTONE; 2'-AMINOCHALCONES; NITROSTYRENES; REDUCTION; DISCOVERY; EFFICIENT; INDOLES; ROUTE;
D O I：
10.1021/acs.joc.0c01344
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
An efficient and straightforward Bronsted-acid mediated cascade process was developed, involving cyclization of readily available beta-ketonitriles into 2-aminofurans, and their subsequent recyclization into 2-(1H-indol-2-yl)acetamides is developed. This synthetic route opens a new avenue for an expeditious assembly of
引用
收藏
页码：12128 / 12146
页数：19
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