Synthesis of 2-(1H-Indol-2-yl)acetamides via Bronsted Acid-Assisted Cyclization Cascade

被引：15

作者：

Aksenov, Nicolai A. ^{[1
]}

Aksenov, Dmitrii A. ^{[1
]}

Skomorokhov, Anton A. ^{[1
]}

Prityko, Lidiya A. ^{[1
]}

Aksenov, Alexander V. ^{[1
]}

Griaznov, Georgii D. ^{[2
]}

Rubin, Michael ^{[1
,2
]}

机构：

[1] North Caucasus Fed Univ, Dept Chem, Stavropol 355009, Russia

[2] Univ Kansas, Dept Chem, Lawrence, KS 66045 USA

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2020年 / 85卷 / 19期

基金：

俄罗斯科学基金会;

关键词：

INHIBITORY-ACTIVITY; MICHAEL ADDITION; HISTONE; 2'-AMINOCHALCONES; NITROSTYRENES; REDUCTION; DISCOVERY; EFFICIENT; INDOLES; ROUTE;

D O I：

10.1021/acs.joc.0c01344

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient and straightforward Bronsted-acid mediated cascade process was developed, involving cyclization of readily available beta-ketonitriles into 2-aminofurans, and their subsequent recyclization into 2-(1H-indol-2-yl)acetamides is developed. This synthetic route opens a new avenue for an expeditious assembly of

引用

页码：12128 / 12146

页数：19

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