Plk1: unexpected roles in DNA replication

被引：34

作者：

Mandal, Ranadip ^{[1
]}

Strebhardt, Klaus ^{[1
]}

机构：

[1] Goethe Univ Frankfurt, Dept Gynecol & Obstet, D-60590 Frankfurt, Germany

来源：

CELL RESEARCH | 2013年 / 23卷 / 11期

关键词：

POLO-LIKE KINASE-1; CANCER-THERAPY; CENTROSOME; PHOSPHORYLATION; PROGRESSION; ACTIVATION; CELLS;

D O I：

10.1038/cr.2013.130

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

FOR20, a conserved centrosomal protein, is essential for Plk1 to localize to the centrosome during the S phase and regulate DNA replication. The absence of either Plk1 or FOR20 can stall the cell cycle by a previously unknown intra-S phase centrosomal checkpoint.

引用

页码：1251 / 1253

页数：3

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