Utilization of a silkworm model for understanding host-pathogen interactions

被引：0

作者：

Kaito, C. ^{[1
]}

Yoshikai, H. ^{[1
]}

Sekimizu, K. ^{[1
]}

机构：

[1] Univ Tokyo, Grad Sch Pharmaceut Sci, Tokyo 1130033, Japan

来源：

ISJ-INVERTEBRATE SURVIVAL JOURNAL | 2012年 / 9卷 / 02期

关键词：

insect model; innate immune factor; bacteria; fungi; virulence factor; ENTEROHEMORRHAGIC ESCHERICHIA-COLI; STAPHYLOCOCCUS-AUREUS VIRULENCE; PSEUDOMONAS-AERUGINOSA PAO1; BOMBYX-MORI; SARCOPHAGA-PEREGRINA; PARALYTIC PEPTIDE; INFECTION MODEL; BACTERIAL; PROTEIN; INACTIVATION;

D O I：

暂无

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Studies of the interactions between humans and pathogenic microorganisms require adequate representative animal infection models. Further, the availability of invertebrate models overcomes the ethical and financial issues of studying vertebrate materials. Insects have an innate immune system that is conserved in mammals. The recent utilization of silkworms as an animal infection model led to the identification of novel virulence genes of human pathogenic microorganisms and novel innate immune factors in the silkworm. The silkworm infection model is effective for identifying and evaluating novel factors involved in host-pathogen interactions.

引用

页码：163 / 168

页数：6

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