RNA Dependent RNA Polymerases: Insights from Structure, Function and Evolution

被引：249
作者：
Venkataraman, Sangita [1 ]
Prasad, Burra V. L. S. [2 ]
Selvarajan, Ramasamy [3 ]
机构：
[1] Acharya Nagarjuna Univ, Dept Biotechnol, Nagarjuna Nagar, Guntur, India
[2] Amity Univ Haryana, Amity Inst Biotechnol, Manesar 122413, Gurgaon, India
[3] ICAR Natl Res Ctr Banana, Tiruchirappalli 620102, India
来源：
VIRUSES-BASEL | 2018年 / 10卷 / 02期
关键词：
RNA viruses; RNA-dependent RNA polymerase; domains; motifs; structure-based Phylogeny; inhibitor complexes; VESICULAR STOMATITIS-VIRUS; GDD SEQUENCE MOTIF; Q-BETA REPLICASE; CRYSTAL-STRUCTURE; ACTIVE-SITE; NONNUCLEOSIDE INHIBITORS; MUTATIONAL ANALYSIS; PROTEIN; NUCLEOTIDE; REVEALS;
D O I：
10.3390/v10020076
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
RNA dependent RNA polymerase (RdRp) is one of the most versatile enzymes of RNA viruses that is indispensable for replicating the genome as well as for carrying out transcription. The core structural features of RdRps are conserved, despite the divergence in their sequences. The structure of RdRp resembles that of a cupped right hand and consists of fingers, palm and thumb subdomains. The catalysis involves the participation of conserved aspartates and divalent metal ions. Complexes of RdRps with substrates, inhibitors and metal ions provide a comprehensive view of their functional mechanism and offer valuable insights regarding the development of antivirals. In this article, we provide an overview of the structural aspects of RdRps and their complexes from the Group III, IV and V viruses and their structure-based phylogeny.
引用
收藏
页数：23
相关论文
共 126 条
[91]   Structural insight into cap-snatching and RNA synthesis by influenza polymerase [J].
Reich, Stefan ;
Guilligay, Delphine ;
Pflug, Alexander ;
Malet, Helene ;
Berger, Imre ;
Crepin, Thibaut ;
Hart, Darren ;
Lunardi, Thomas ;
Nanao, Max ;
Ruigrok, Rob W. H. ;
Cusack, Stephen .
NATURE, 2014, 516 (7531) :361-+
[92]   Structure of the RNA-directed RNA Polymerase from the cystovirus φ 12 [J].
Ren, Zhen ;
Franklin, Matthew C. ;
Ghose, Ranajeet .
PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS, 2013, 81 (08) :1479-1484
[93]   Membranous Replication Factories Induced by Plus-Strand RNA Viruses [J].
Romero-Brey, Ines ;
Bartenschlager, Ralf .
VIRUSES-BASEL, 2014, 6 (07) :2826-2857
[94]  
Saiz JC, 2017, ANTIMICROB AGENTS CH, V61, DOI [10.1128/AAC.00411-17, 10.1128/aac.00411-17]
[95]  
SANKAR S, 1992, J BIOL CHEM, V267, P10168
[96]   Norovirus RNA-dependent RNA polymerase: A computational study of metal-binding preferences [J].
Shaik, Md Munan ;
Bhattacharjee, Nicholus ;
Feliks, Mikolaj ;
Ng, Kenneth K. -S. ;
Field, Martin J. .
PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS, 2017, 85 (08) :1435-1445
[97]   Structural basis of viral RNA-dependent RNA polymerase catalysis and translocation [J].
Shu, Bo ;
Gong, Peng .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2016, 113 (28) :E4005-E4014
[98]   PROSITE, a protein domain database for functional characterization and annotation [J].
Sigrist, Christian J. A. ;
Cerutti, Lorenzo ;
de Castro, Edouard ;
Langendijk-Genevaux, Petra S. ;
Bulliard, Virginie ;
Bairoch, Amos ;
Hulo, Nicolas .
NUCLEIC ACIDS RESEARCH, 2010, 38 :D161-D166
[99]   Nucleoside, Nucleotide, and Non-Nucleoside Inhibitors of Hepatitis C Virus NS5B RNA-Dependent RNA-Polymerase [J].
Sofia, Michael J. ;
Chang, Wonsuk ;
Furman, Phillip A. ;
Mosley, Ralph T. ;
Ross, Bruce S. .
JOURNAL OF MEDICINAL CHEMISTRY, 2012, 55 (06) :2481-2531
[100]   The Influenza Virus Polymerase Complex: An Update on Its Structure, Functions, and Significance for Antiviral Drug Design [J].
Stevaert, Annelies ;
Naesens, Lieve .
MEDICINAL RESEARCH REVIEWS, 2016, 36 (06) :1127-1173
45678910111213