Serum salusin-α levels are inversely correlated with the presence and severity of coronary artery disease

被引：19

作者：

Du, Song-Lin ^{[1
]}

Wang, Wu-Jun ^{[1
]}

Wan, Jun ^{[1
]}

Wang, Yue-Gang ^{[2
]}

Wang, Zhen-Kang ^{[1
]}

Zhang, Zhen ^{[1
]}

机构：

[1] Southern Med Univ, Dept Thorac & Cardiovasc Surg, Nanfang Hosp, Guangzhou 510515, Guangdong, Peoples R China

[2] Southern Med Univ, Dept Cardiol, Nanfang Hosp, Guangzhou 510515, Guangdong, Peoples R China

来源：

SCANDINAVIAN JOURNAL OF CLINICAL & LABORATORY INVESTIGATION | 2013年 / 73卷 / 04期

关键词：

Disease; cardiovascular; coronary artery disease; biological factors; salusin-alpha; BIOACTIVE PEPTIDES; HEART-DISEASE; ATHEROSCLEROSIS; INDIVIDUALS; BIOMARKERS;

D O I：

10.3109/00365513.2013.783227

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

We sought to measure serum salusin-alpha levels in patients with coronary artery disease (CAD) and to assess their correlation with the severity of the disease. We enrolled 172 patients with CAD and 91 controls. We assessed the angiographic severity of CAD by coronary atherosclerosis index (CAI) and detected serum salusin-alpha levels by enzyme-linked immunosorbent assay (ELISA). We demonstrated that CAD patients had significantly lower serum salusin-alpha levels compared to controls. Moreover, serum salusin-alpha levels were independently and negatively correlated with the presence and severity of CAD. These findings indicated that salusin-alpha might serve as a potential biomarker for predicting the development and progression of CAD.

引用

收藏

页码：339 / 343

页数：5

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