Canthin-6-one alkaloids from Picrasma quassioides and their cytotoxic activity

被引：39

作者：

Jiang, Mei-Xiang ^{[1
]}

Zhou, Ying-Jun ^{[1
]}

机构：

[1] Cent S Univ, Sch Pharmaceut Sci, Changsha, Hunan, Peoples R China

来源：

JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH | 2008年 / 10卷 / 11期

关键词：

Picrasma quassioides; Simaroubaceae; canthin-6-one alkaloids; cytotoxic activity;

D O I：

10.1080/10286020802277956

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

A new alkaloid, 4,5-dimethoxy-10-hydroxycanthin-6-one (1), was isolated from the stem of Picrasma quassioides Bennet (Simaroubaceae) together with four known canthin-6-one alkaloids, 8-hydroxycanthin-6-one (2), 4,5-dimethoxycanthin-6-one (3), 5-hydroxy-4-methoxycanthin-6-one (4), and 3-methylcanthin-5,6-dione (5). Their structures were elucidated on the basis of spectroscopic data. The cytotoxic activity of the canthin-6-one alkaloids was evaluated using human nasopharyngeal carcinoma (CNE2) and human liver cancer (Bel-7402) cell lines. Among these isolates, compounds 1-4 exhibited significant cytotoxic activity against CNE2 cell line.

引用

页码：1009 / 1012

页数：4

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