Inactivation of myeloma cancer cells by helium and argon plasma jets: The effect comparison and the key reactive species

被引：17

作者：

Chen, Zeyu ^{[1
]}

Cui, Qingjie ^{[2
]}

Chen, Chen ^{[1
]}

Xu, Dehui ^{[1
]}

Liu, Dingxin ^{[1
]}

Chen, H. L. ^{[3
]}

Kong, Michael G. ^{[1
,3
,4
]}

机构：

[1] Xi An Jiao Tong Univ, Ctr Plasma Biomed, State Key Lab Elect Insulat & Power Equipment, Xian 710049, Shaanxi, Peoples R China

[2] Xi An Jiao Tong Univ, Sch Life Sci & Technol, Xian 710049, Shaanxi, Peoples R China

[3] Old Dominion Univ, Frank Reidy Ctr Bioelect, Norfolk, VA 23508 USA

[4] Old Dominion Univ, Dept Elect & Comp Engn, Norfolk, VA 23529 USA

来源：

PHYSICS OF PLASMAS | 2018年 / 25卷 / 02期

基金：

中国国家自然科学基金;

关键词：

ROS; PEROXYNITRITE; DISCHARGE; NITRATION; OXYGEN; GAS;

D O I：

10.1063/1.5010724

中图分类号：

O35 [流体力学]; O53 [等离子体物理学];

学科分类号：

070204 ; 080103 ; 080704 ;

摘要：

In plasma cancer therapy, the inactivation of cancer cells under plasma treatment is closely related to the reactive oxygen and nitrogen species (RONS) induced by plasmas. Quantitative study on the plasma-induced RONS that related to cancer cells apoptosis is critical for advancing the research of plasma cancer therapy. In this paper, the effects of several reactive species on the inactivation of LP-1 myeloma cancer cells are comparatively studied with variable working gas composition, surrounding gas composition, and discharge power. The results show that helium plasma jet has a higher cell inactivation efficiency than argon plasma jet under the same discharge power. By comparing the concentration of aqueous phase reactive species and the cell inactivation efficiency under different working gases and discharge powers, it is demonstrated that the inactivation efficiency of LP-1 myeloma cancer cells is strongly correlated with the concentration of peroxynitrite (ONOOH/ONOO-). Published by AIP Publishing.

引用

页数：6

共 36 条

[1] The NOX family of ROS-generating NADPH oxidases: Physiology and pathophysiology [J].