Design of tumor-homing and pH-responsive polypeptide-doxorubicin nanoparticles with enhanced anticancer efficacy and reduced side effects

被引：35

作者：

Hu, Jin ^{[1
]}

Xie, Lining ^{[1
]}

Zhao, Wenguo ^{[1
]}

Sun, Mengmeng ^{[1
]}

Liu, Xinyu ^{[1
]}

Gao, Weiping ^{[1
]}

机构：

[1] Tsinghua Univ, Sch Med, Dept Biomed Engn, Beijing 100084, Peoples R China

来源：

CHEMICAL COMMUNICATIONS | 2015年 / 51卷 / 57期

基金：

中国国家自然科学基金;

关键词：

PROTEIN; NANOTECHNOLOGY; THERAPEUTICS; NANOCARRIERS; ACCUMULATION; CONJUGATE; MECHANISM;

D O I：

10.1039/c5cc04035c

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Tumor-homing and pH-responsive polypeptide-drug nanoparticles for targeted cancer therapy are precisely designed by site-specific drug conjugation to a bioactive and well-defined elastin-like polypeptide through an acid-labile linker. In a murine cancer model, these nanoparticles show significantly better anti-tumor efficacy and less systemic toxicity than not only free drugs, but also polypeptide-drug nanoparticles without the tumor-homing function.

引用

页码：11405 / 11408

页数：4

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