The Qingdao Twin Registry: A Status Update

被引：36

作者：

Duan, Haiping ^{[1
]}

Ning, Feng ^{[2
]}

Zhang, Dongfeng ^{[3
]}

Wang, Shaojie ^{[1
]}

Zhang, Dong ^{[4
]}

Tan, Qihua ^{[5
,6
]}

Tian, Xiaocao ^{[1
,7
]}

Pang, Zengchang ^{[1
]}

机构：

[1] Qingdao Ctr Dis Control & Prevent, Qingdao 266033, Peoples R China

[2] Univ Helsinki, Hjelt Inst, Dept Publ Hlth, Helsinki, Finland

[3] Qingdao Univ, Coll Med, Dept Publ Hlth, Qingdao 266071, Peoples R China

[4] Jiaonan Ctr Dis Control & Prevent, Qingdao, Peoples R China

[5] Univ So Denmark, Inst Publ Hlth, Odense, Denmark

[6] Odense Univ Hosp, Dept Clin Genet, DK-5000 Odense, Denmark

[7] Shandong Univ, Dept Publ Hlth, Jinan 250100, Peoples R China

来源：

TWIN RESEARCH AND HUMAN GENETICS | 2013年 / 16卷 / 01期

基金：

美国国家卫生研究院; 中国国家自然科学基金;

关键词：

Chinese twins; registry; phenotypes; genome-wide association analysis; cohort study; METABOLIC SYNDROME; URIC-ACID; CARDIOVASCULAR MORTALITY; WORLDWIDE VARIATIONS; DIABETES-MELLITUS; ATOPIC ECZEMA; ALCOHOL-USE; SMOKING; CHINESE; PREVALENCE;

D O I：

10.1017/thg.2012.113

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

In 1998, the Qingdao Twin Registry was initiated as the main part of the Chinese National Twin Registry. By 2005, a total of 10,655 twin pairs had been recruited. Since then new twin cohorts have been sampled, with one longitudinal cohort of adolescent twins selected to explore determinants of metabolic disorders and health behaviors during puberty and young adulthood. Adult twins have been sampled for studying heritability of multiple phenotypes associated with metabolic disorders. In addition, an elderly twin cohort has been recruited with a focus on genetic studies of aging-related phenotypes using twin modeling and genome-wide association analysis. Cross-cultural collaborative studies have been carried out between China, Denmark, Finland, and US cohorts. Ongoing data collection and analysis for the Qingdao Twin Registry will be discussed in this article.

引用

页码：79 / 85

页数：7

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