Emerging molecular networks in Burkitt's lymphoma

被引：11
作者：
Mangani, Davide [1 ,2 ,3 ]
Roberti, Annalisa [1 ]
Rizzolio, Flavio [1 ,4 ]
Giordano, Antonio [1 ,5 ]
机构：
[1] Temple Univ, Sbarro Inst Canc Res & Mol Med, Coll Sci & Technol, Ctr Biotechnol, Philadelphia, PA 19122 USA
[2] Human Hlth Fdn, Terni, PG, Italy
[3] Human Hlth Fdn, Spoleto, PG, Italy
[4] Natl Canc Inst IRCCS Aviano, Aviano, Italy
[5] Univ Siena, Dept Human Pathol & Oncol, I-53100 Siena, Italy
来源：
JOURNAL OF CELLULAR BIOCHEMISTRY | 2013年 / 114卷 / 01期
基金：
欧洲研究理事会;
关键词：
BURKITT'S LYMPHOMA; PROTEASOME; miRNA; C-MYC; CELL; EXPRESSION; PROLIFERATION; INACTIVATION; COOPERATE; LINES;
D O I：
10.1002/jcb.24358
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Burkitt's lymphoma (BL), one of the most aggressive tumors affecting humans, characterized by the constitutive activation of the Myc oncogene together with the alteration of many other genetic and epigenetic factors. Among them, the INK4a/ARF locus has been well documented to play a central role in BL. Recently, we have discovered that simultaneous deregulation of both DNA methylation patterns and the ubiquitin-dependent proteolysis system is required to completely inactive the INK4/ARF locus, opening new possibilities for treating Burkitt's lymphoma. In this review, we integrate our discovery with the general view of BL and propose a new comprehensive approach to analyze and manage this aggressive disease. J. Cell. Biochem. 114: 3538, 2012. (C) 2012 Wiley Periodicals, Inc.
引用
收藏
页码：35 / 38
页数：4
相关论文
共 34 条
[11]   B-CELL PROLIFERATION AND INDUCTION OF EARLY G(1)-REGULATING PROTEINS BY EPSTEIN-BARR-VIRUS MUTANTS CONDITIONAL FOR EBNA2 [J].
KEMPKES, B ;
SPITKOVSKY, D ;
JANSENDURR, P ;
ELLWART, JW ;
KREMMER, E ;
DELECLUSE, HJ ;
ROTTENBERGER, C ;
BORNKAMM, GW ;
HAMMERSCHMIDT, W .
EMBO JOURNAL, 1995, 14 (01) :88-96
[12]   Notch1, Notch2, and Epstein-Barr virus-encoded nuclear antigen 2 signaling differentially affects proliferation and survival of Epstein-Barr virus-infected B cells [J].
Kohlhof, Hella ;
Hampel, Franziska ;
Hoffmann, Reinhard ;
Burtscher, Helmut ;
Weidle, Ulrich H. ;
Holzel, Michael ;
Eick, Dirk ;
Zimber-Strobl, Ursula ;
Strobl, Lothar J. .
BLOOD, 2009, 113 (22) :5506-5515
[13]   Regulation of p53 stability by Mdm2 [J].
Kubbutat, MHG ;
Jones, SN ;
Vousden, KH .
NATURE, 1997, 387 (6630) :299-303
[14]   B cells under influence:: Transformation of B cells by Epstein-Barr virus [J].
Küppers, R .
NATURE REVIEWS IMMUNOLOGY, 2003, 3 (10) :801-812
[15]   MYC translocation-negative classical Burkitt lymphoma cases: an alternative pathogenetic mechanism involving miRNA deregulation [J].
Leucci, E. ;
Cocco, M. ;
Onnis, A. ;
De Falco, G. ;
van Cleef, P. ;
Bellan, C. ;
van Rijk, A. ;
Nyagol, J. ;
Byakika, B. ;
Lazzi, S. ;
Tosi, P. ;
van Krieken, H. ;
Leoncini, L. .
JOURNAL OF PATHOLOGY, 2008, 216 (04) :440-450
[16]   p14ARF homozygous deletion or MDM2 overexpression in Burkitt lymphoma lines carrying wild type p53 [J].
Lindström, MS ;
Klangby, U ;
Wiman, KG .
ONCOGENE, 2001, 20 (17) :2171-2177
[17]  
LITTLEWOOD TD, 1992, ONCOGENE, V7, P1783
[18]   A systems biology approach to prediction of oncogenes and molecular perturbation targets in B-cell lymphomas [J].
Mani, Kartik M. ;
Lefebvre, Celine ;
Wang, Kai ;
Lim, Wei Keat ;
Basso, Katia ;
Dalla-Favera, Riccardo ;
Califano, Andrea .
MOLECULAR SYSTEMS BIOLOGY, 2008, 4 (1)
[19]   Revealing strengths and weaknesses of methods for gene network inference [J].
Marbach, Daniel ;
Prill, Robert J. ;
Schaffter, Thomas ;
Mattiussi, Claudio ;
Floreano, Dario ;
Stolovitzky, Gustavo .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2010, 107 (14) :6286-6291
[20]   Epstein-Barr virus nuclear protein EBNA3C is required for cell cycle progression and growth maintenance of lymphoblastoid cells [J].
Maruo, Seiji ;
Wu, Yi ;
Ishikawa, Satoko ;
Kanda, Teru ;
Iwakiri, Dai ;
Takada, Kenzo .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2006, 103 (51) :19500-19505
1234