Emerging molecular networks in Burkitt's lymphoma

被引：11
作者：
Mangani, Davide [1 ,2 ,3 ]
Roberti, Annalisa [1 ]
Rizzolio, Flavio [1 ,4 ]
Giordano, Antonio [1 ,5 ]
机构：
[1] Temple Univ, Sbarro Inst Canc Res & Mol Med, Coll Sci & Technol, Ctr Biotechnol, Philadelphia, PA 19122 USA
[2] Human Hlth Fdn, Terni, PG, Italy
[3] Human Hlth Fdn, Spoleto, PG, Italy
[4] Natl Canc Inst IRCCS Aviano, Aviano, Italy
[5] Univ Siena, Dept Human Pathol & Oncol, I-53100 Siena, Italy
来源：
JOURNAL OF CELLULAR BIOCHEMISTRY | 2013年 / 114卷 / 01期
基金：
欧洲研究理事会;
关键词：
BURKITT'S LYMPHOMA; PROTEASOME; miRNA; C-MYC; CELL; EXPRESSION; PROLIFERATION; INACTIVATION; COOPERATE; LINES;
D O I：
10.1002/jcb.24358
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Burkitt's lymphoma (BL), one of the most aggressive tumors affecting humans, characterized by the constitutive activation of the Myc oncogene together with the alteration of many other genetic and epigenetic factors. Among them, the INK4a/ARF locus has been well documented to play a central role in BL. Recently, we have discovered that simultaneous deregulation of both DNA methylation patterns and the ubiquitin-dependent proteolysis system is required to completely inactive the INK4/ARF locus, opening new possibilities for treating Burkitt's lymphoma. In this review, we integrate our discovery with the general view of BL and propose a new comprehensive approach to analyze and manage this aggressive disease. J. Cell. Biochem. 114: 3538, 2012. (C) 2012 Wiley Periodicals, Inc.
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收藏
页码：35 / 38
页数：4
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