Application of ionic liquid-TiO2 nanoparticle modified carbon paste electrode for the voltammetric determination of benserazide in biological samples

An ionic liquid-TiO2 nanoparticle modified carbon paste electrode (IL-TiO2/CPE) was used as a fast and sensitive tool for the investigation of the electrochemical oxidation of benserazide using voltammetry. This modified electrode has been fabricated using hydrophilic ionic liquid (n-hexyl-3-methylimidazolium hexafluoro phosphate) as a binder. The modified electrode offers a considerable improvement in voltammetric sensitivity toward benserazide, compared to the bare electrode. Using differential pulse voltammetry (DPV), the electrocatalytic oxidation peak current of benserazide shows a linear calibration curve in the range of 1.0-600 mu mol L-1 benserazide. The limit of detection was equal to 0.4 mu mol L-1. The relative standard deviation (RSD%) for eight successive assays of 10 mu mol L-1 benserazide was 1.1%. Finally, the proposed method was successfully applied to the determination of benserazide in real samples such as blood serum and urine. (c) 2012 Elsevier B.V. All rights reserved.