Striatal neuronal loss correlates with clinical motor impairment in Huntington's disease

被引:66
作者
Guo, Zhihong [1 ,2 ]
Rudow, Gay [1 ]
Pletnikova, Olga [1 ]
Codispoti, Kari-Elise [1 ]
Orr, Brent A. [1 ]
Crain, Barbara J. [1 ]
Duan, Wenzhen [2 ]
Margolis, Russell L. [2 ]
Rosenblatt, Adam [2 ]
Ross, Christopher A. [2 ,3 ,4 ]
Troncoso, Juan C. [1 ,5 ]
机构
[1] Johns Hopkins Univ, Sch Med, Dept Pathol, Div Neuropathol, Baltimore, MD 21205 USA
[2] Johns Hopkins Univ, Sch Med, Dept Psychiat & Behav Sci, Div Neurobiol, Baltimore, MD 21205 USA
[3] Johns Hopkins Univ, Sch Med, Dept Neurosci, Baltimore, MD 21205 USA
[4] Johns Hopkins Univ, Sch Med, Dept Pharmacol & Mol Sci, Baltimore, MD 21205 USA
[5] Johns Hopkins Univ, Sch Med, Dept Neurol, Baltimore, MD 21205 USA
关键词
putamen; subthalamic nucleus; medium spiny neurons; DARPP-32; stereology; SUBTHALAMIC NUCLEUS; MOVEMENT-DISORDERS; DIFFERENTIAL LOSS; HEMIBALLISMUS; SEVERITY; GENE; RAT;
D O I
10.1002/mds.25159
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Huntington's disease (HD) is characterized clinically by chorea, motor impairment, psychiatric manifestations, and dementia. Atrophy of the striatum is the neuropathological hallmark of HD, and previous studies have suggested that striatal atrophy correlates more closely with motor impairment than with chorea. Motor impairment, as measured by motor impairment score, correlates with functional disability in HD patients, but chorea does not. In this study, we investigated the relation between neuronal loss and these motor features. We conducted neuropathological and stereologic assessments of neurons in putamen and subthalamic nuclei in HD patients and age-matched controls. In putamen, we estimated the total number and volume of medium spiny neurons labeled with dopamine- and cAMP-regulated phosphoprotein 32 kDa (DARPP-32). In subthalamic nuclei, we estimated the total number of neurons on hematoxylin & eosin/luxol fast blue stains. In putamen of HD, immunohistochemistry showed DARPP-32 neuronal atrophy with extensive disruption of neurites and neuropil; stereologic studies found significant decreases in both the number and size of DARPP-32 neurons; we also detected a significant reduction of overall putamen volume in HD patients, compared to controls. In subthalamic nuclei, there was a mild, but significant, neuronal loss in the HD group. The loss of neurons in putamen and subthalamic nuclei as well as putaminal atrophy were significantly correlated with severity of motor impairment, but not with chorea. Our findings suggest that neuronal loss and atrophy in striatum and neuronal loss in subthalamic nuclei contribute specifically to the motor impairment of HD, but not to chorea. (c) 2012 Movement Disorder Society
引用
收藏
页码:1379 / 1386
页数:8
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