Liver/spleen volume ratio as a predictor of prognosis in primary biliary cirrhosis

被引：32

作者：

Murata, Yosuke ^{[1
]}

Abe, Masanori ^{[1
]}

Hiasa, Yoichi ^{[1
]}

Azemoto, Nobuaki ^{[1
]}

Kumagi, Teru ^{[1
]}

Furukawa, Shinya ^{[1
]}

Matsuura, Bunzo ^{[1
]}

Michitaka, Kojiro ^{[1
]}

Horiike, Norio ^{[1
]}

Onji, Morikazu ^{[1
]}

机构：

[1] Ehime Univ, Grad Sch Med, Dept Gastroenterol & Metabol, Shitsukawa, Toon 7910295, Japan

来源：

JOURNAL OF GASTROENTEROLOGY | 2008年 / 43卷 / 08期

关键词：

primary biliary cirrhosis; splenomegaly; portal hypertension;

D O I：

10.1007/s00535-008-2202-9

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Background. The course of primary biliary cirrhosis (PBC) is determined by clinical symptoms and histological findings. The present study examined the prognostic importance of imaging parameters in PBC. Methods. The volumes of the liver and spleen of patients with PBC were assessed by computed tomography (CT). The volume ratio of liver to spleen (LV/SV ratio) was evaluated and used for further analyses. Results. The prognosis was significantly poorer in PBC patients with a low, rather than high, LV/SV ratio. The Cox proportional hazard regression model showed that the serum bilirubin level and the LV/SV ratio could predict the prognosis of PBC patients. In addition, the LV/SV ratio was significantly lower in patients who developed symptoms (s-PBC) than in those who remained asymptomatic (a-PBC) during the observation period. Conclusions. The LV/SV ratio is of prognostic importance in patients with PBC.

引用

页码：632 / 636

页数：5

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