Modulation of the cardiovascular system by leptin

被引：19
作者：
Abel, E. Dale [2 ,3 ]
Sweeney, Gary [1 ]
机构：
[1] York Univ, Dept Biol, Toronto, ON M3J 1P3, Canada
[2] Univ Utah, Sch Med, Div Endocrinol Metab & Diabet, Salt Lake City, UT USA
[3] Univ Utah, Sch Med, Program Mol Med, Salt Lake City, UT USA
来源：
BIOCHIMIE | 2012年 / 94卷 / 10期
基金：
加拿大健康研究院; 美国国家卫生研究院;
关键词：
Leptin; Cardiovascular; Metabolic syndrome; Heart failure; Obesity; HEART-FAILURE; HYPERTROPHIC CARDIOMYOPATHY; BLOOD-PRESSURE; MALONYL-COA; OBESITY; MECHANISMS; RESISTANCE; HYPERTENSION; METABOLISM; ACTIVATION;
D O I：
10.1016/j.biochi.2012.03.019
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
It is well established that individuals with the metabolic syndrome have a significantly increased risk of cardiovascular disease and much effort has been expended to elicit the underlying mechanisms. Various studies have proposed that excessive or deficient physiological effects mediated by leptin make an important contribution, yet many paradoxical observations often preclude a clear definition of the role of leptin. This review article will briefly discuss principal and most recent evidence on direct and indirect regulation of the cardiovascular system by leptin, focusing on cardiac structural and functional as well as vascular effects. (C) 2012 Elsevier Masson SAS. All rights reserved.
引用
收藏
页码：2097 / 2103
页数：7
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