No association between MTHFR C677T polymorphism and completed suicide

被引：11

作者：

Chojnicka, Izabela ^{[1
]}

Sobczyk-Kopciol, Agnieszka ^{[2
]}

Fudalej, Marcin ^{[3
]}

Fudalej, Sylwia ^{[5
]}

Wojnar, Marcin ^{[4
,5
]}

Waskiewicz, Anna ^{[6
]}

Broda, Grazyna ^{[6
]}

Strawa, Katarzyna ^{[1
]}

Pawlak, Aleksandra ^{[3
]}

Krajewski, Pawel ^{[3
]}

Ploski, Rafal ^{[1
]}

机构：

[1] Med Univ Warsaw, Dept Med Genet, PL-02106 Warsaw, Poland

[2] Med Univ Warsaw, Dept Gen Biol & Parasitol, PL-02106 Warsaw, Poland

[3] Med Univ Warsaw, Dept Forens Med, PL-02106 Warsaw, Poland

[4] Univ Michigan, Dept Psychiat, Ann Arbor, MI 48109 USA

[5] Med Univ Warsaw, Dept Psychiat, PL-02106 Warsaw, Poland

[6] Inst Cardiol, Dept Cardiovasc Dis Epidemiol Prevent & Hlth Prom, Warsaw, Poland

来源：

GENE | 2012年 / 511卷 / 01期

关键词：

rs1801133; Methylenetetrahydrofolate reductase (NADPH2); Molecular genetics; Single nucleotide polymorphism; Risk factor; REDUCTASE GENE POLYMORPHISMS; FOLATE METABOLIC PATHWAY; METHYLENETETRAHYDROFOLATE REDUCTASE; HOMOCYSTEINE CONCENTRATIONS; CARDIOVASCULAR-DISEASE; BIPOLAR DISORDER; FOLIC-ACID; RISK; POPULATION; METAANALYSIS;

D O I：

10.1016/j.gene.2012.09.019

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

MTHFR C677T polymorphism (rs1801133) was associated with numerous psychiatric conditions but no prior study investigated whether it predisposes to completed suicide. We typed rs1801133 in 692 suicide victims and 3257 controls representative of a Polish adult population (the WOBASZ cohort). Although we had a power of 0.8 to detect (at alpha 0.05) an allelic OR = 1.19, we did not find significant difference among suicides vs. controls in the prevalence of the MTHFR 6771 allele (OR = 1.02, p = 0.759) or the TT genotype (OR = 1.01, p = 0.926). Since among controls we found an association between TT and depression defined by Beck Depression Inventory (BDI, OR = 1.61, p = 0.049) we also compared suicides with controls without signs of depression (BDI <= 11) but found no association (OR = 1.0, p = 0.976). Analyses within suicides showed trends (not significant after Bonferroni correction) for correlations between the dose of the T allele and age at death among males and blood ethanol concentration among females, who committed suicide under the influence of alcohol. We conclude that MTHFR C677T polymorphism is not a risk factor for completed suicide. The sex-specific trends for correlations between rs1801133 and age at death, and blood ethanol concentration should be studied further. (C) 2012 Elsevier B.V All rights reserved.

引用

页码：118 / 121

页数：4

共 39 条

[1] Homocysteine and Depression in Later Life [J].