Risk genotypes and haplotypes of the GLUT1 gene for type 2 diabetic nephropathy in the Tunisian population

被引：10

作者：

Makni, K. ^{[1
]}

Jarraya, F. ^{[1
,2
]}

Rebai, M. ^{[3
]}

Mnif, F. ^{[4
]}

Boudawara, M. ^{[5
]}

Hamza, N. ^{[5
]}

Rekik, N. ^{[4
]}

Abid, M. ^{[4
]}

Hachicha, J. ^{[2
]}

Granier, C. ^{[6
]}

Rebai, A. ^{[3
]}

Ayadi, H. ^{[1
]}

机构：

[1] Ctr Biotechnol Sfax, Res Unit Target Diag & Therapeut Human Pathol, Sfax, Tunisia

[2] Hedi Chaker Hosp, Dept Nephrol, Sfax, Tunisia

[3] Ctr Biotechnol Sfax, Res Unit Bioinformat, Sfax, Tunisia

[4] Hedi Chaker Hosp, Dept Endocrinol, Sfax, Tunisia

[5] Social Natl Case Sfax, Lab Anal, Sfax, Tunisia

[6] Fac Pharm Montpellier, Ctr Pharmacol & Biotechnol Hlth,CNRS,UMR 5094, CNRS,BIO RAD, FRE 3009, Montpellier, France

来源：

ANNALS OF HUMAN BIOLOGY | 2008年 / 35卷 / 05期

关键词：

diabetic nephropathy; GLUT1; gene; risk haplotype;

D O I：

10.1080/03014460802247142

中图分类号：

Q98 [人类学];

学科分类号：

030303 ;

摘要：

Objective: Diabetic nephropathy (DN) is a long-term complication of both type 1 and type 2 diabetes. Genetic studies on DN have been of little help so far, since several genetic association studies have shown conflicting results. Here we report the findings of a case-control study on five SNPs in the glucose transporter 1 (GLUT1) gene. The study investigated the association of five GLUT1 genotypes and haplotypes with DN. Research design and methods: All subjects, 126 DN (cases) and 273 type 2 diabetes (controls), were genotyped using the polymerase chain reaction restriction fragment length polymorphism. Results: The TT and the AA genotypes of the Haell and Enh2 SNP1, increased the risk of DN. The study also identified CGT as the highest risk haplotype (4.4-fold) followed by CAT with an increased risk of DN of 2.6-fold. Conclusions: The GLUT1 gene confers susceptibility to DN in type 2 diabetes patients in the Tunisian population.

引用

页码：490 / 498

页数：9

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