Investigating Microglia in Health and Disease: Challenges and Opportunities

被引：35
|
作者：
Miron, Veronique E. [1 ]
Priller, Josef [2 ,3 ,4 ,5 ]
机构：
[1] Univ Edinburgh, Queens Med Res Inst, Med Res Council, Ctr Reprod Hlth, Edinburgh, Midlothian, Scotland
[2] Charite Univ Med Berlin, Dept Neuropsychiat, Berlin, Germany
[3] Charite Univ Med Berlin, Lab Mol Psychiat, Berlin, Germany
[4] DZNE, Berlin, Germany
[5] Univ Edinburgh, UK Dementia Res Inst, Edinburgh, Midlothian, Scotland
来源：
TRENDS IN IMMUNOLOGY | 2020年 / 41卷 / 09期
基金：
英国医学研究理事会;
关键词：
CELLS; BRAIN; MACROPHAGES; FATE; DIFFERENTIATION; MYELINOGENESIS; PHENOTYPE; TURNOVER; DYNAMICS; SURVIVAL;
D O I：
10.1016/j.it.2020.07.002
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Microglia are tissue-resident macrophages implicated in central nervous system (CNS) development, homeostasis, and response to injury. Recent advances in transcriptomics, multiplex protein expression analysis, and experimental depletion of microglia have cemented their importance. However, it is still unclear which models are best suited to investigate microglia and explore their function in human disease. Here, we discuss issues regarding off-targeting during experimental manipulation, and differences and similarities between human and rodent microglia. With new developments in transgenic lines and human-rodent chimeras, we anticipate that in coming years, a clearer picture of microglia function in health and disease will emerge.
引用
收藏
页码：785 / 793
页数：9
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