Sesquiterpene Lactones: From Weed to Remedy

被引：0

作者：

Peterkova, Lucie ^{[1
]}

Rimpelova, Silvie ^{[1
,3
]}

Kmonickova, Eva ^{[1
,2
,3
]}

Ruml, Tomas ^{[1
]}

机构：

[1] Vysoka Skola Chem Technol Praze, Ustav Biochem & Mikrobiol, Tech 5, Prague 16628 6, Czech Republic

[2] AV CR, Ustav Expt Med, Vvi, Videnska 1083, Prague 14220 4, Czech Republic

[3] Univ Karlova, Lekarska Fak Plzni, Ustav Farmakol & Toxikol, Alej Svobody 1655-76, Plzen 32300, Czech Republic

来源：

CHEMICKE LISTY | 2019年 / 113卷 / 03期

关键词：

natural compounds; sesquiterpene lactones; sarco/endoplasmic reticulum Ca2+-ATPase (SERCA); thapsigargin; trilobolide; parthenolide; cynaropicrin; anti-cancer activity; NF-KAPPA-B; PLASMODIUM-FALCIPARUM; OXIDATIVE STRESS; QUANTITATIVE STRUCTURE; ANTICANCER ACTIVITY; NITRIC-OXIDE; CYNAROPICRIN; ARTEMISININ; THAPSIGARGIN; CA2+-ATPASE;

D O I：

暂无

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Sesquiterpene lactones are bioactive natural compounds with anticancer, antiprotozoal, immunomodulatory, antibacterial and antiviral activity which have potential for drug development. The aim of this review article is to provide a brief insight into the field of sesquiterpene lactones: the main mechanisms of their biological actions, as well as particular compounds, are described, some of which have already become a basis of a drug development and are being tested in clinical trials.

引用

页码：149 / 155

页数：7

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