Sesquiterpene Lactones: From Weed to Remedy

被引：0
作者：
Peterkova, Lucie [1 ]
Rimpelova, Silvie [1 ,3 ]
Kmonickova, Eva [1 ,2 ,3 ]
Ruml, Tomas [1 ]
机构：
[1] Vysoka Skola Chem Technol Praze, Ustav Biochem & Mikrobiol, Tech 5, Prague 16628 6, Czech Republic
[2] AV CR, Ustav Expt Med, Vvi, Videnska 1083, Prague 14220 4, Czech Republic
[3] Univ Karlova, Lekarska Fak Plzni, Ustav Farmakol & Toxikol, Alej Svobody 1655-76, Plzen 32300, Czech Republic
来源：
CHEMICKE LISTY | 2019年 / 113卷 / 03期
关键词：
natural compounds; sesquiterpene lactones; sarco/endoplasmic reticulum Ca2+-ATPase (SERCA); thapsigargin; trilobolide; parthenolide; cynaropicrin; anti-cancer activity; NF-KAPPA-B; PLASMODIUM-FALCIPARUM; OXIDATIVE STRESS; QUANTITATIVE STRUCTURE; ANTICANCER ACTIVITY; NITRIC-OXIDE; CYNAROPICRIN; ARTEMISININ; THAPSIGARGIN; CA2+-ATPASE;
D O I：
暂无
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Sesquiterpene lactones are bioactive natural compounds with anticancer, antiprotozoal, immunomodulatory, antibacterial and antiviral activity which have potential for drug development. The aim of this review article is to provide a brief insight into the field of sesquiterpene lactones: the main mechanisms of their biological actions, as well as particular compounds, are described, some of which have already become a basis of a drug development and are being tested in clinical trials.
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页码：149 / 155
页数：7
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