Selenocysteine-containing proteins in mammals

被引：83

作者：

Gladyshev, VN ^{[1
]}

Hatfield, DL

机构：

[1] Univ Nebraska, Dept Biochem, Lincoln, NE 68588 USA

[2] NCI, Sect Mol Biol Selenium, Basic Res Lab,Div Basic Sci, NIH, Bethesda, MD 20892 USA

来源：

JOURNAL OF BIOMEDICAL SCIENCE | 1999年 / 6卷 / 03期

关键词：

selenocysteine; selenoproteins; selenoenzymes; glutathione peroxidase; iodothyronine deiodinase; thioredoxin reductase; selenoprotein P; codon UGA;

D O I：

10.1159/000025383

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Since the recent discovery of selenocysteine as the 21st amino acid in protein, the field of selenium biology has rapidly expanded. Twelve mammalian selenoproteins have been characterized to date and each contains selenocysteine that is incorporated in response to specific UGA code words. These selenoproteins have different cellular functions, but in those selenoproteins for which the function is known, selenocysteine is located at the active center. The presence of selenocysteine at critical sites in naturally occurring selenoproteins provides an explanation for the important role of selenium in human health and development. This review describes known mammalian selenoproteins and discusses recent developments and future directions in the selenium field.

引用

页码：151 / 160

页数：10

共 103 条

[1] 1-CHLORO-2,4-DINITROBENZENE IS AN IRREVERSIBLE INHIBITOR OF HUMAN THIOREDOXIN REDUCTASE - LOSS OF THIOREDOXIN DISULFIDE REDUCTASE-ACTIVITY IS ACCOMPANIED BY A LARGE INCREASE IN NADPH OXIDASE ACTIVITY [J].