Norovirus GII.4 Virus-like Particles Recognize Galactosylceramides in Domains of Planar Supported Lipid Bilayers

被引：29

作者：

Bally, Marta ^{[1
]}

Rydell, Gustaf E. ^{[3
]}

Zahn, Raphael ^{[5
,6
]}

Nasir, Waqas ^{[2
]}

Eggeling, Christian ^{[7
]}

Breimer, Michael E. ^{[4
]}

Svensson, Lennart ^{[8
]}

Hook, Fredrik ^{[1
]}

Larson, Gran ^{[2
]}

机构：

[1] Chalmers Univ Technol, Dept Appl Phys, SE-41133 Gothenburg, Sweden

[2] Univ Gothenburg, Dept Clin Chem & Transfus Med, Sahlgrenska Acad, Gothenburg, Sweden

[3] Inst Curie, CNRS UMR144, Traff Signaling & Delivery Lab, Ctr Rech, F-75231 Paris, France

[4] Univ Gothenburg, Dept Surg, Sahlgrenska Acad, Gothenburg, Sweden

[5] Univ Zurich, Inst Biomed Engn, Lab Biosensors & Bioelect, CH-8006 Zurich, Switzerland

[6] Swiss Fed Inst Technol, Zurich, Switzerland

[7] Max Planck Inst Biophys Chem, Leipzig, Germany

[8] Linkoping Univ, Div Mol Virol, S-58183 Linkoping, Sweden

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2012年 / 51卷 / 48期

基金：

瑞士国家科学基金会; 瑞典研究理事会;

关键词：

galactosylceramide; glycolipids; noroviruses; supported lipid bilayer; viruses; QUARTZ-CRYSTAL MICROBALANCE; EPITHELIAL-CELLS; QUANTITATIVE MEASUREMENTS; GLYCOLIPID RECEPTORS; PLASMA-MEMBRANES; GLYCOSPHINGOLIPIDS; BINDING; SURFACE; PHASE; MICROSTRUCTURE;

D O I：

10.1002/anie.201205972

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A sticky situation: Domain-dependent recognition of the glycosphingolipid galactosylceramide by norovirus-like particles (see picture; red/yellow) is shown using supported lipid bilayers (purple) as model membranes. Optimal ligand presentation is found to promote strong binding to GalCer. This presentation can be found at the edges of the glycosphingolipid-enriched domains (green) and binding is repressed in the absence of these domains. Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：12020 / 12024

页数：5

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