Laser Patterning of Bacterial Cellulose Hydrogel and its Modification With Gelatin and Hydroxyapatite for Bone Tissue Engineering

被引：50

作者：

Wang Jing ^{[1
,2
]}

Yang Chunxi ^{[3
,4
]}

Wan Yizao ^{[1
]}

Luo Honglin ^{[1
]}

He Fang ^{[1
]}

Dai Kerong ^{[2
]}

Huang Yuan ^{[1
]}

机构：

[1] Tianjin Univ, Sch Mat Sci & Engn, Tianjin 300072, Peoples R China

[2] Tianjin Polytech Univ, Composites Res Inst, Minist Educ, Key Lab Adv Text Composites, Tianjin 300387, Peoples R China

[3] Shanghai Jiao Tong Univ, Sch Med, Peoples Hosp 9, Dept Orthoped, Shanghai 200030, Peoples R China

[4] Tongji Univ, Sch Med, Shanghai Peoples Hosp 10, Dept Orthoped, Shanghai 200092, Peoples R China

来源：

SOFT MATERIALS | 2013年 / 11卷 / 02期

关键词：

Bacterial cellulose; Chondrogenic cell; Gelatin; Hydroxyapatite; Laser patterning; MECHANICAL-PROPERTIES; GRAFT SUBSTITUTE; FILMS; SCAFFOLDS; COLLAGEN; APATITE; HYDROXYLAPATITE; MINERALIZATION; BIOMATERIALS; MEMBRANE;

D O I：

10.1080/1539445X.2011.611204

中图分类号：

T [工业技术];

学科分类号：

08 ;

摘要：

Bacterial cellulose (BC) is considered a promising and cost-efficient nanoscaffold for tissue engineering; however, the absence of large pores for cell ingrowth and enough biological properties restricts its practical use as tissue engineering scaffold. In this work, a novel porous BC membrane with regular vertical pore arrays was obtained via laser patterning technique. Then, this porous BC membrane was modified with gelatin (Gel) and hydroxyapatite (HAp), respectively, to enhance its activity. After the modification, thin Gel and HAp coatings formed on the surfaces of nanofibers in the pore wall, which had no influence on the original refined network structures. In order to review the cytocompatibility of the obtained scaffolds, chondrogenic rat cells were seeded on scaffolds. The results showed that chondrogenic rat cell could keep viability on scaffolds, and the scaffolds support chondrogenic rat cell attachment and proliferation.

引用

页码：173 / 180

页数：8