What determines adherence to treatment in cardiovascular disease prevention? Protocol for a mixed methods preference study

被引：12

作者：

Jan, Stephen ^{[1
]}

Usherwood, Tim ^{[2
]}

Brien, Jo Anne ^{[3
]}

Peiris, David ^{[1
]}

Rose, John ^{[4
]}

Hayman, Noel ^{[5
]}

Howard, Kirsten ^{[6
]}

Redfern, Julie ^{[1
]}

Laba, Tracey ^{[1
]}

Cass, Alan ^{[1
]}

Patel, Anushka ^{[1
]}

机构：

[1] George Inst Global Hlth, Camperdown, NSW, Australia

[2] Univ Sydney, Western Clin Sch, Dept Gen Practice, Westmead, NSW 2145, Australia

[3] Univ Sydney, Fac Pharm, Sydney, NSW 2006, Australia

[4] Inala Indigenous Hlth Serv, Brisbane, Qld, Australia

[5] Univ Sydney, Inst Transport & Logist Studies, Sydney, NSW 2006, Australia

[6] Univ Sydney, Sch Publ Hlth, Sydney, NSW 2006, Australia

来源：

BMJ OPEN | 2011年 / 1卷 / 02期

基金：

澳大利亚国家健康与医学研究理事会; 英国医学研究理事会;

关键词：

D O I：

10.1136/bmjopen-2011-000372

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Background: Significant gaps exist between guidelines-recommended therapies for cardiovascular disease prevention and current practice. Fixed-dose combination pills ('polypills') potentially improve adherence to therapy. This study is a preference study undertaken in conjunction with a clinical trial of a polypill and seeks to examine the underlying reasons for variations in treatment adherence to recommended therapy. Methods/design: A preference study comprising: (1) Discrete Choice Experiment for patients; and (2) qualitative study of patients and providers. Both components will be conducted on participants in the trial. A joint model combining the observed adherence in the clinical trial (revealed preference) and the Discrete Choice Experiment data (stated preference) will be estimated. Estimates will be made of the marginal effect (importance) of each attribute on overall choice, the extent to which respondents are prepared to trade-off one attribute for another and predicted values of the level of adherence given a fixed set of attributes, and contextual and socio-demographic characteristics. For the qualitative study, a thematic analysis will be used as a means of exploring in depth the preferences and ultimately provide important narratives on the experiences and perspectives of individuals with regard to adherence behaviour. Ethics and dissemination: Primary ethics approval was received from Sydney South West Area Health Service Human Research Ethics Committee (Royal Prince Alfred Hospital zone). In addition to usual scientific forums, the findings will be reported back to the communities involved in the studies through site-specific reports and oral presentations.

引用

页数：7

共 27 条

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