Long-Term Hepatitis B Virus Surface Antigen Decay in HIV-1/Hepatitis B Virus-Coinfected Adults Initiating a Tenofovir-Containing Regimen

被引：5

作者：

Tuaillon, E. ^{[1
,2
,3
]}

Lozano, C. ^{[2
]}

Kuster, N. ^{[2
]}

Poinso, A. ^{[2
]}

Kania, D. ^{[1
,5
]}

Nagot, N. ^{[1
,4
]}

Mondain, A. M. ^{[2
]}

Pageaux, G. P. ^{[6
,7
]}

Ducos, J. ^{[1
,2
]}

Van de Perre, P. ^{[1
,2
]}

Reynes, J. ^{[3
,8
]}

机构：

[1] Univ Montpellier I, INSERM, U1058, Montpellier, France

[2] CHRU Montpellier, Dept Bacteriol Virol, Montpellier, France

[3] CHRU Montpellier, Dept Malad Infect & Trop, Montpellier, France

[4] CHRU Montpellier, Dept Informat Med, Montpellier, France

[5] Ctr Muraz, Lab Virol, Bobo Dioulasso, Burkina Faso

[6] CHRU Montpellier, INSERM, U632, Montpellier, France

[7] CHRU Montpellier, Dept Hepatogastroenterol, Montpellier, France

[8] UMI 233, Montpellier, France

来源：

JOURNAL OF CLINICAL MICROBIOLOGY | 2012年 / 50卷 / 09期

关键词：

ALPHA-2A;

D O I：

10.1128/JCM.00971-12

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Hepatitis B virus (HBV) surface antigen (HBsAg) decay was explored in HIV-1- and HBV-coinfected patients beginning antiretroviral (ARV) therapy containing tenofovir disoproxil fumarate (TDF). The mean HBsAg decay was 0.38 log(10) IU/ml/year (95% confidence interval [CI], 0.71 to 0.05) in 18 patients with sustained plasma HIV-1 RNA suppression and 0.15 log(10) IU/ml/year (0.21 to 0.09) in 12 patients experiencing HIV-1 virologic failure due to suboptimal adherence to ARV (P = 0.17). We estimated that six of these 18 patients will attain HBsAg values below 10 IU/ml after 10 years of treatment.

引用

页码：3096 / 3098

页数：3

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