共 31 条
The value of systemic inflammatory markers in identifying malignancy in mucinous pancreatic cystic neoplasms
被引:6
作者:
Zhou, Wentao
[1
]
Rong, Yefei
[1
]
Kuang, Tiantao
[1
]
Xu, Yadong
[2
]
Shen, Xiaojing
[3
]
Ji, Yuan
[3
]
Lou, Wenhui
[2
]
Wang, Dansong
[1
]
机构:
[1] Fudan Univ, Zhong Shan Hosp, Dept Gen Surg, Shanghai, Peoples R China
[2] Fudan Univ, Zhong Shan Hosp, Dept Pancreat Surg, Shanghai, Peoples R China
[3] Fudan Univ, Zhong Shan Hosp, Dept Pathol, Shanghai, Peoples R China
来源:
基金:
中国国家自然科学基金;
关键词:
systemic inflammatory markers;
pancreatic cystic neoplasm;
invasive carcinoma;
platelet-to-lymphocyte ratio;
lymphocyte-to-monocyte ratio;
NEUTROPHIL-TO-LYMPHOCYTE;
FUKUOKA CONSENSUS GUIDELINES;
GROWTH-FACTOR;
MANAGEMENT;
RATIO;
PLATELET;
SENDAI;
PREDICTOR;
SURVIVAL;
CANCER;
D O I:
10.18632/oncotarget.23310
中图分类号:
R73 [肿瘤学];
学科分类号:
100214 ;
摘要:
The treatment decision-making of mucinous pancreatic cystic neoplasm (PCN) has become a common clinical problem since the diagnostic accuracy of current tests in identifying malignancies in pancreatic cysts is limited. In this study, we aimed to validate the predictive value of systemic inflammatory factors in detecting malignant PCNs. Two hundred and forty-five patients with pathologically confirmed mucinous PCNs in a single Chinese institution were retrospectively analyzed. Receiver operating characteristic (ROC) curves were calculated to determine the optimal cut-off values and measure the diagnostic value. The results showed that neutrophil count (P = 0.009), lymphocyte count (P = 0.002), neutrophil-to-lymphocyte ratio (NLR, P < 0.001), platelet-to-lymphocyte ratio (PLR, P < 0.001) and lymphocyte-to-monocyte ratio (LMR, P < 0.001) were distributed differently among the various differentiation groups of PCN. The univariate analyses indicated that a neutrophil count >= 2.8 x 10(9)/L (P = 0.024), lymphocyte count <= 1.9 x 10(9)/L (P < 0.001), PLR >= 125 (P < 0.001), NLR >= 1.96 (P < 0.001), and LMR <= 4.29 (P < 0.001) were significantly associated with invasive carcinomas in PCN patients. In addition, the multivariate analyses demonstrated that PLR >= 125 and LMR <= 4.29 were independent predictors of invasive malignancies. The ROC curves exhibited the malignant detection utility of the independent factor-based predictive model with an area under the curve (AUC) of 0.858 (P < 0.001). In conclusion, systemic inflammatory markers provide a supportive and easily accessible tool for the preoperative diagnoses of malignant PCNs.
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页码:115561 / 115569
页数:9
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