The history of Distilbene® (Diethylstilbestrol) told to grandchildren - the transgenerational effect

被引：21

作者：

Fenichel, Patrick ^{[1
]}

Brucker-Davis, Francoise ^{[1
]}

Chevalier, Nicolas ^{[1
]}

机构：

[1] Nice Univ Hosp, Inserm U1065 C3M, Endocrinol Diabetol & Reprod Unit, Nice, France

来源：

ANNALES D ENDOCRINOLOGIE | 2015年 / 76卷 / 03期

关键词：

Distilbene (R); Vaginal adenocarcinoma; Hypospadias; Fetal exposure; Endocrine disruptors; Transgenerational effect; EXPOSED IN-UTERO; CANCER-RISK; WOMEN; HYPOSPADIAS; PREGNANCY; ESTROGEN; MICE; SONS; INHERITANCE; DESCENDANTS;

D O I：

10.1016/j.ando.2015.03.008

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The Distilbene (R) story is a dramatic episode which belongs to the history of medicine. It provided several useful lessons such as the importance of evidence-based medicine and the hazard to develop treatments during pregnancy without careful animal verifications. However, this experience has also provided unexpected progress by suggesting new pathophysiological concepts: fetal programming of adult diseases and/or transgenerational transmission of environmental effects through epigenetic modifications. (C) 2015 Published by Elsevier Masson SAS.

引用

页码：253 / 259

页数：7

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