Changes in MMP-9 and TIMP-1 Concentrations in Cerebrospinal Fluid after 1 Week of Treatment of Childhood Bacterial Meningitis

被引：13
作者：
Roine, Irmeli [1 ]
Pelkonen, Tuula [2 ,3 ,4 ,6 ]
Lauhio, Anneli [4 ,5 ]
Lappalainen, Maija
Cruzeiro, Manuel Leite [2 ]
Bernardino, Luis [2 ]
Tervahartiala, Taina [7 ,8 ]
Sorsa, Timo [7 ,8 ,9 ]
Peltola, Heikki [3 ,4 ,6 ]
机构：
[1] Univ Diego Portales, Fac Med, Santiago, Chile
[2] Hosp Pediat David Bernardino, Luanda, Angola
[3] Helsinki Univ Hosp, Childrens Hosp, Helsinki, Finland
[4] Univ Helsinki, Helsinki, Finland
[5] Helsinki Univ Hosp, Inflammat Ctr, Infect Dis, Helsinki, Finland
[6] Helsinki Univ Hosp, Virol & Immunol, Lab Serv HUSLAB, Helsinki, Finland
[7] Univ Helsinki, Dept Oral & Maxillofacial Dis, Helsinki, Finland
[8] Helsinki Univ Hosp, Helsinki, Finland
[9] Karolinska Inst, Dept Dent Med, Div Periodontol, Huddinge, Sweden
来源：
JOURNAL OF CLINICAL MICROBIOLOGY | 2015年 / 53卷 / 07期
关键词：
MATRIX METALLOPROTEINASES; CONTROLLED-TRIAL; MATRIX-METALLOPROTEINASE-9;
D O I：
10.1128/JCM.00714-15
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
We explored the changes of the initially highly upgraded cerebrospinal fluid matrix metalloproteinase 9 (MMP-9) and tissue inhibitor of MMP 1 (TIMP-1) response during recovery of childhood bacterial meningitis and their association with outcome. The sizes of these changes varied substantially, but a steeper decrease in the MMP-9 and an increase of the TIMP-1 concentrations augured a better outcome.
引用
收藏
页码：2340 / 2342
页数：3
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