Oxidation of a Anticholinergic Drug Atropine Sulfate Monohydrate by Alkaline Copper(III) Periodate Complex: A Kinetic and Mechanistic Study

被引：5

作者：

Byadagi, Kirthi S. ^{[1
]}

Hosahalli, Rajeshwari V. ^{[1
]}

Nandibewoor, Sharanappa T. ^{[1
]}

Chimatadar, Shivamurti A. ^{[1
]}

机构：

[1] Karnatak Univ, PG Dept Studies Chem, Dharwad 580003, Karnataka, India

来源：

ZEITSCHRIFT FUR PHYSIKALISCHE CHEMIE-INTERNATIONAL JOURNAL OF RESEARCH IN PHYSICAL CHEMISTRY & CHEMICAL PHYSICS | 2012年 / 226卷 / 03期

关键词：

Atropine Sulfate; Diperiodatocuprate(III); Oxidation; Kinetics; Mechanism; DIPERIODATOCUPRATE(III);

D O I：

10.1524/zpch.2012.0201

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

The oxidation of a anticholinergic drug, Atropine sulfate monohydrate (ASM) by diperiodatocuprate(III) (DPC) has been investigated spectrophotometrically in aqueous alkaline medium at a constant ionic strength of 0.50 mol dm(-3). The reaction between diperiodatocuprate(111) and atropine sulfate exhibits 1 : 2 stoichiometry (atropine sulfate : diperiodatocuprate(III)). The main oxidation products were identified and confirmed by spectral studies including HZ, H-1 NMR and GC-MS. A suitable mechanism is proposed. The order with respect to diperiodatocuprate(111) concentration was unity, while the order with respect to atropine sulfate concentration was less than unity over the concentration range studied. The rates increased with an increase in alkali concentration and decreased with an increase in periodate concentration. The activation parameters with respect to slow step of the mechanism were calculated and the thermodynamic quantities were also determined. Kinetic experiments suggest that [Cu(OH)(2)(H3IO6)](-) is the reactive species of copper(III).

引用

页码：233 / 249

页数：17

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