An extremely rare case of small-cell lung cancer harboring variant 2 of the EML4-ALK fusion gene

被引：32

作者：

Toyokawa, Gouji ^{[1
]}

Takenoyama, Mitsuhiro ^{[1
]}

Taguchi, Kenichi ^{[2
]}

Toyozawa, Ryo ^{[1
]}

Inamasu, Eiko ^{[1
]}

Kojo, Miyako ^{[1
]}

Shiraishi, Yoshimasa ^{[1
]}

Morodomi, Yosuke ^{[1
]}

Takenaka, Tomoyoshi ^{[1
]}

Hirai, Fumihiko ^{[1
]}

Yamaguchi, Masafumi ^{[1
]}

Seto, Takashi ^{[1
]}

Shimokawa, Mototsugu ^{[3
]}

Ichinose, Yukito ^{[1
]}

机构：

[1] Kyushu Natl Canc Ctr, Dept Thorac Oncol, Minami Ku, Fukuoka 8111395, Japan

[2] Kyushu Natl Canc Ctr, Inst Clin Res, Canc Pathol Lab, Fukuoka 8111395, Japan

[3] Kyushu Natl Canc Ctr, Inst Clin Res, Fukuoka 8111395, Japan

来源：

LUNG CANCER | 2013年 / 81卷 / 03期

关键词：

Small-cell lung cancer; Oncogenic driver mutation; EML4-ALK; MUTATIONS;

D O I：

10.1016/j.lungcan.2013.05.022

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Anaplastic lymphoma kinase (ALK) fuses echinoderm microtubule-associated protein-like 4 (EML4) to acquire a transforming activity in lung adenocarcinomas. However, the presence of an EML4-ALK fusion gene in other lung cancer histologies is an extremely rare phenomenon. A 43-year-old female was referred to our department due to dyspnea on effort and left back pain. Computed tomography (CT) showed a large mass in the upper lobe of the left lung and a massive left pleural effusion, while a CT-guided needle biopsy confirmed a diagnosis of small-cell lung cancer (SCLC). Surprisingly, the tumor was genetically considered to harbor the EML4-ALK fusion gene (variant 2). Although the patient underwent two regimens of cytotoxic chemotherapy for SCLC, she died approximately seven months after the administration of first-line chemotherapy. Our analysis of 30 consecutive patients with SCLC for EML4-ALK revealed that two patients, including the current patient and a patient we previously reported, harbored the EML4-ALK fusion gene. (c) 2013 Elsevier Ireland Ltd. All rights reserved.

引用

页码：487 / 490

页数：4

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