Cerebellar atrophy after acute phenytoin intoxication

被引：33

作者：

Kuruvilla, T

Bharucha, NE

机构：

[1] Department of Neuroepidemiology, Bombay Hospital, Bombay

[2] Department of Neuroepidemiology, MRC, Bombay Hospital, 12- Marine lines

来源：

EPILEPSIA | 1997年 / 38卷 / 04期

关键词：

cerebellar atrophy; acute PHT intoxication;

D O I：

10.1111/j.1528-1157.1997.tb01742.x

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

There is some evidence that long-term phenytoin (PHT) use may occasionaly give rise to irreversible cerebellar atrophy, but it is unclear whether such changes can occur after acute PHT intoxication. We describe a 38-year-old patient with accidental acute PHT overdose who developed severe cerebellar atrophy. This case provides evidence that acute PHT intoxication can, on rare occasions, result in irreversible cerebellar degeneration.

引用

页码：500 / 502

页数：3

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