Cell Dissemination in Pancreatic Cancer

被引：9
作者：
Kim, Jungsun [1 ,2 ,3 ]
机构：
[1] Oregon Hlth & Sci Univ, Canc Early Detect Adv Res Ctr, Knight Canc Inst, 2720 SW Moody Ave, Portland, OR 97201 USA
[2] Oregon Hlth & Sci Univ, Knight Canc Inst, Canc Biol Res Program, 2730 S Moody Ave, Portland, OR 97201 USA
[3] Oregon Hlth & Sci Univ, Dept Mol & Med Genet, Sch Med, 3222 SW Res Dr, Portland, OR 97239 USA
来源：
CELLS | 2022年 / 11卷 / 22期
关键词：
cell dissemination; collective cell migration; epithelial-mesenchymal transition (EMT); adherens junctions; DUCTAL ADENOCARCINOMA; PERINEURAL INVASION; INTRAEPITHELIAL NEOPLASIA; EPITHELIAL PLASTICITY; LYMPHATIC-SYSTEM; VENOUS INVASION; NEURAL INVASION; BETA-CATENIN; E-CADHERIN; METASTASIS;
D O I：
10.3390/cells11223683
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Pancreatic cancer is a disease notorious for its high frequency of recurrence and low survival rate. Surgery is the most effective treatment for localized pancreatic cancer, but most cancer recurs after surgery, and patients die within ten years of diagnosis. The question persists: what makes pancreatic cancer recur and metastasize with such a high frequency? Herein, we review evidence that subclinical dormant pancreatic cancer cells disseminate before developing metastatic or recurring cancer. We then discuss several routes by which pancreatic cancer migrates and the mechanisms by which pancreatic cancer cells adapt. Lastly, we discuss unanswered questions in pancreatic cancer cell migration and our perspectives.
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页数：16
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