Study of In Vivo Biocompatibility and Dynamics of Replacement of Rat Shin Defect with Porous Granulated Bioceramic Materials

被引：12

作者：

Chissov, V. I. ^{[1
]}

Sviridova, I. K. ^{[1
]}

Sergeeva, N. S. ^{[1
]}

Frank, G. A. ^{[1
]}

Kirsanova, V. A. ^{[1
]}

Achmedova, S. A. ^{[1
]}

Reshetov, I. V. ^{[1
]}

Filjushin, M. M. ^{[1
]}

Barinov, S. M. ^{[2
]}

Fadeeva, I. V. ^{[2
]}

Komlev, V. S. ^{[2
]}

机构：

[1] Russian Acad Sci, PA Hertzen Moscow Oncol Inst, Moscow, Russia

[2] Russian Acad Sci, Inst Physicochem Problems Ceram Mat, Moscow, Russia

来源：

BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2008年 / 146卷 / 01期

关键词：

bioceramics; biocompatibility; bone tissue defect;

D O I：

10.1007/s10517-008-0222-3

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Biocompatibility of porous granulated bioceramic materials (hydroxyapatite, beta-tricalcium phosphate, hydroxyapatite-beta-tricalcium phosphate complex (80: 20 wt%), carbonate-containing hydroxyapatite, and silicon-containing hydroxyapatite) was shown in a subcutaneous test on BDF1 mice. Dynamic (up to 8 months) observation showed gradual replacement of the granular substance with de novo forming bone tissue with hemopoiesis foci on a model of fenestral defect in the shin bone in Wistar rats. By the rate of resorption, the materials rank as follows: silicon-containing hydroxyapatite<hydroxyapatite<hydroxyapatite-beta-tricalcium phosphate<beta-tricalcium phosphate<carbonate-containing hydroxyapatite. The rate of resorption in bone tissue defect was significantly higher than in the subcutaneous test, but lagged behind (even for tricalcium phosphate and carbonate-containing hydroxyapatite) bone tissue formation de novo.

引用

页码：139 / 143

页数：5

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