The Relationship between Ischemia Modified Albumin and Oxidative Stress Parameters in Patients with Cardiac Syndrome X

被引:6
作者
Demir, B. [1 ]
Ozyazgan, S. [2 ]
Korkmaz, G. G. [3 ]
Karakaya, O. [1 ]
Aciksari, G. [1 ]
Uygun, T. [1 ]
Onal, B. [2 ]
Uzun, H. [4 ]
机构
[1] Bakirkoy Dr Sadi Konuk Educ & Res Hosp, Dept Cardiol, Istanbul, Turkey
[2] Istanbul Univ, Cerrahpasa Fac Med, Dept Med Pharmacol & Clin Pharmacol, TR-34303 Istanbul, Turkey
[3] Kirklareli Univ, Sch Hlth, Kirklareli, Turkey
[4] Istanbul Univ, Cerrahpasa Fac Med, Dept Med Biochem, TR-34303 Istanbul, Turkey
关键词
cardiac syndrome X; ischemia modified albumin; oxidative stress; coronary angiography; CORONARY MICROVASCULAR DYSFUNCTION; C-REACTIVE-PROTEIN; STABLE ANGINA-PECTORIS; MYOCARDIAL-ISCHEMIA; ARTERY-DISEASE; CHEST-PAIN; CLINICAL PRESENTATION; MARKER; WOMEN; PATHOPHYSIOLOGY;
D O I
10.7754/Clin.Lab.2013.121142
中图分类号
R446 [实验室诊断]; R-33 [实验医学、医学实验];
学科分类号
1001 ;
摘要
Background: The objective of this study was to evaluate the serum levels of ischemia modified albumin and oxidative stress parameters in patients with cardiac syndrome X. Methods: A total of 61 patients, composed of 32 consecutive patients (24 female, 8 male, average age: 47.63 +/- 9.49 years) diagnosed with cardiac syndrome X by coronary angiography (initially performed following the identification of ischemia by exercise stress test or myocardial perfusion scintigraphy) and a control group of 29 consecutive patients (15 female, 14 male, average age: 49.59 +/- 11.68 years) with similar features without cardiac syndrome X were included in the study. The levels of the ischemia modified albumin (IMA), ferric reducing antioxidant power (FRAP), prooxidant-antioxidant balance (PAB), and advanced protein oxidation products (AOPP) were determined by colorimetric methods. Results: Patients have significantly higher PAB, AOPP, and IMA levels in the patient group than in the control group (p < 0.01, p < 0.001, and p < 0.02, respectively). Also, serum triglyceride (p < 0.005) and hs-CRP (p < 0.0001) levels were significantly higher in the patient group (p < 0.01, p < 0.001, and p < 0.02, respectively). We found that there was a significant correlation between hs-CRP, plasma PAB (r: 0.258; p < 0.05), AOPP (r: 0.459; p < 0.001), and triglyceride levels (r: 0.404; p < 0.01). Plasma AOPP levels were also significantly positive correlated with triglyceride levels (r: 0.463; p < 0.001). In addition, during the correlation analysis performed on the patient group, a positive correlation was observed between the levels of IMA with the levels of plasma PAB and plasma AOPP (r: 0,994; p < 0.01 and r: 0.857; p < 0.05, respectively) In a multiple linear regression analysis, AOPP levels were significantly related with hs-CRP and triglyceride (R-2: 0.380, p < 0.0001 and p < 0.05). Simple linear regression analysis was performed between plasma PAB (as dependent variable) and hs-CRP levels. Plasma PAB levels were related with hs-CRP (R-2: 0.258, p < 0.05). Using the receiver-operator characteristic (ROC) curve, the best cut-off values for predicting cardiac syndrome X of PAD, AOPP, IMA, and hs-CRP levels were 88.1 arbitrary units, 68.5 kloramin T mu mol/L, 7.17 U/mL, and 1.09 mg/dL, respectively. Conclusions: Based on the results of our study, the increase in oxidative stress during cardiac syndrome X appears to be related to elevated levels of IMA. Treatment modalities that decrease oxidative stress might be beneficial for the treatment of cardiac syndrome X.
引用
收藏
页码:1319 / 1329
页数:11
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